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SATB1 in Malignant T Cells
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2018 (English)In: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 138, no 8, p. 1805-1815Article in journal (Refereed) Published
Abstract [en]

Deficient expression of SATB1 hampers thymocyte development and results in inept T-cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides, the most frequent variant of cutaneous T-cell lymphoma. Here, we report on a disease stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. STAT5 inhibited SATB1 expression through induction of microRNA-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32), whereas increased SATB1 expression had the opposite effect, indicating that the microRNA-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5 and its upstream activator JAK3 triggered increased SATB1 expression and a concomitant suppression of IL-5 and IL-9 expression in malignant T cells. In conclusion, we provide a mechanistic link between the proto-oncogenic JAK3/STAT5/microRNA-155 pathway, SATB1, and cytokines linked to CTCL severity and progression, indicating that SATB1 dysregulation is involved in cutaneous T-cell lymphoma pathogenesis.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 138, no 8, p. 1805-1815
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:umu:diva-150355DOI: 10.1016/j.jid.2018.03.1526ISI: 000439136200029PubMedID: 29751003Scopus ID: 2-s2.0-85048705717OAI: oai:DiVA.org:umu-150355DiVA, id: diva2:1238457
Available from: 2018-08-13 Created: 2018-08-13 Last updated: 2018-08-13Bibliographically approved

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Persson, Jenny L.

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Fredholm, SimonWillerslev-Olsen, AndreasMet, ÖzcanBlümel, EddaBuus, Terkild B.Krejsgaard, ThorbjørnPersson, Jenny L.
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Department of Molecular Biology (Faculty of Medicine)
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Journal of Investigative Dermatology
Dermatology and Venereal Diseases

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  • apa
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