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A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
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2018 (engelsk)Inngår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 361, nr 6409, s. 1386-+-, artikkel-id eaat8849Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Here we show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging strand preference increases markedly in cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, due to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading vs lagging strands, and that Dbp3-Dpb4 plays a significant role in this poorly understood process.

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American Association for the Advancement of Science , 2018. Vol. 361, nr 6409, s. 1386-+-, artikkel-id eaat8849
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Identifikatorer
URN: urn:nbn:se:umu:diva-150963DOI: 10.1126/science.aat8849ISI: 000446142200050PubMedID: 30115745OAI: oai:DiVA.org:umu-150963DiVA, id: diva2:1240374
Forskningsfinansiär
NIH (National Institute of Health), R35GM118015Swedish Cancer SocietySwedish Research Council
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Special Issue: SI

Tilgjengelig fra: 2018-08-21 Laget: 2018-08-21 Sist oppdatert: 2018-10-31bibliografisk kontrollert

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