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Effects of triclosan in breast milk on the infant fecal microbiome
Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 203, s. 467-473Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Triclosan is frequently used for its antimicrobial properties and has been detected in human serum, urine, and breast milk. Animal and molecular studies have shown that triclosan exerts a wide range of adverse health effects at both high (ppm) and low (ppb) concentrations. Since triclosan is of growing concern to human and environmental health, there is a need to improve extraction procedures and to study additional effects from triclosan exposure. In this study, we have improved triclosan extraction from breast milk by using salt (MgSO4) to reduce emulsion formation and increase water polarity and water (similar to 80%) to enhance the overall extraction efficiency (similar to 3.5 fold). This extraction method was applied to breast milk samples collected from donors who i) recorded their use of triclosan-containing personal care products and ii) provided matching infant stool samples. Of the participants who had detectable amounts of triclosan in their breast milk, nine (75%) of them reported daily use of triclosan-containing personal care products. Levels of triclosan in breast milk were compared to the donor's infant's fecal microbiome. We found that the bacterial diversity in the fecal microbiome of the infants exposed to breast milk with detectable triclosan levels differed compared to their peers exposed to milk containing non-detectable amounts. This finding implies that exogenous chemicals are impacting microbiome diversity.

sted, utgiver, år, opplag, sider
Elsevier, 2018. Vol. 203, s. 467-473
Emneord [en]
Triclosan, Breast milk, Fecal microbiome, Infant, Personal care products
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-150767DOI: 10.1016/j.chemosphere.2018.03.186ISI: 000432235000054PubMedID: 29635158OAI: oai:DiVA.org:umu-150767DiVA, id: diva2:1244390
Tilgjengelig fra: 2018-08-31 Laget: 2018-08-31 Sist oppdatert: 2018-12-11bibliografisk kontrollert

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