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Intracranial and Intraocular Pressure at the Lamina Cribrosa: Gradient Effects
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2018 (English)In: Current Neurology and Neuroscience Reports, ISSN 1528-4042, E-ISSN 1534-6293, Vol. 18, no 5, article id 25Article, review/survey (Refereed) Published
Abstract [en]

Purpose of Review A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. Recent Findings For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory. Summary Data from studies on the elevated TLCPD as a pathophysiological factor of NTG are equivocal. From the identification of potential postural effects on the cerebrospinal fluid (CSF) communication between the intracranial and retrolaminar space, we hypothesize that the missing link could be a dysfunction of an occlusion mechanism of the optic nerve sheath around the optic nerve. In upright posture, this could cause an elevated TLCPD even with normal ICP and we suggest that this should be investigated as a pathophysiological component in NTG patients.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 18, no 5, article id 25
Keywords [en]
Translamina cribrosa pressure difference, Translaminar pressure difference, Cerebrospinal fluid, Intracranial pressure, Intraocular pressure, Normal tension
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:umu:diva-150706DOI: 10.1007/s11910-018-0831-9ISI: 000430797500004PubMedID: 29651628Scopus ID: 2-s2.0-85045399299OAI: oai:DiVA.org:umu-150706DiVA, id: diva2:1244812
Available from: 2018-09-03 Created: 2018-09-03 Last updated: 2018-09-03Bibliographically approved

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Jóhannesson, GautiEklund, AndersLinden, Christina

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Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)OphthalmologyDepartment of Radiation Sciences
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Current Neurology and Neuroscience Reports
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