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Apolipoprotein A1 distribution pattern in the human Achilles tendon
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine. University of Canberra, Canberra, ACT, Australia ; University of Canberra Research Institute for Sport and Exercise (UCRISE), Canberra, ACT, Australia.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine. Institute of Sport Exercise and Health, University College Hospital London, London, UK.
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2018 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 28, no 5, p. 1506-1513Article in journal (Refereed) Published
Abstract [en]

Metabolic factors such as cholesterol appear to play an important role in the development of Achilles tendinopathy. There is, however, no morphologic proof explaining the link between high cholesterol and tendinopathy. As apolipoprotein A1 (Apo-A1) is essential for reverse cholesterol transport, it may be related to cholesterol overload in tendon. Nothing is known about Apo-A1 expression in tendon tissue. We examined the distribution of Apo-A1 protein in biopsies from normal and tendinopathy-affected human Achilles tendons, and APOA1 mRNA production from cultured human hamstring tenocytes. Specific immunoreactions for Apo-A1 were detected. The tenocytes showed specific Apo-A1 immunoreactions. These reactions were usually distinct in the tendinopathy specimens. While the tendinopathy specimens often showed granular/small deposit reactions, the slender tenocytes of control specimens did not show this pattern. The magnitude of Apo-A1 immunoreactivity was especially marked in the tendinopathy specimens, as there is a high number of tenocytes. Reactions were also seen in the walls of blood vessels located within the tendon tissue proper of both the normal and tendinopathy tendons and within the peritendinous/fatty tissue of the tendinopathy tendons. The reactions were predominantly in the form of deposit reactions within the smooth muscle layer of the vessel walls. Cultured hamstring tenocytes produced APOA1 mRNA. We demonstrated the presence of Apo-A1 in human tendon tissue. This suggests there may be a link between Achilles tendinopathy and cholesterol metabolism. We hypothesize that Apo-A1 may be important for tenocyte and blood vessel function within tendons.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 28, no 5, p. 1506-1513
Keywords [en]
Apo-A1, HDL-C, immunohistochemistry, reverse cholesterol transport, tendinopathy, tendon
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:umu:diva-150705DOI: 10.1111/sms.13051ISI: 000430471900003PubMedID: 29315811Scopus ID: 2-s2.0-85041679099OAI: oai:DiVA.org:umu-150705DiVA, id: diva2:1245313
Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-12-21Bibliographically approved

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Gaida, James EdmundAlfredson, HåkanForsgren, Sture

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