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The antisecretory factor in plasma and breast milk in breastfeeding mothers: a prospective cohort study in Sweden
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 9, article id 1227Article in journal (Refereed) Published
Abstract [en]

Inflammation and infection postpartum threaten the mother and her infant. Human milk provides a defense for the infant, but inflammatory complications like mastitis may lead to the cessation of breastfeeding. Antisecretory factor (AF) has a role in the regulation of secretory processes and inflammation. The objective of the study was to describe AF-levels in plasma and breast milk, and in relation to breast complications. Breastfeeding mothers (n = 95) were consecutively recruited at a Well Baby Clinic in Umeå, Sweden. At inclusion four weeks postpartum, samples of venous blood (10 mL) and breast milk (10 mL) were collected. Active AF was analyzed with ELISA using a monoclonal antibody mAb43, and was detected in all samples of plasma and breast milk with a positive correlation (Spearman coefficient = 0.40, p < 0.001; Pearson correlation = 0.34, p < 0.01). High AF-levels in plasma correlated with high AF-levels in breast milk. The results suggest a co-regulation between active AF in plasma and breastmilk, and/or a local regulation of AF in the breast. Further studies are needed to determine the pathways for the activation of AF-levels in breast milk and plasma.

Place, publisher, year, edition, pages
MDPI, 2018. Vol. 10, no 9, article id 1227
Keywords [en]
antisecretory factor, breast milk, breastfeeding, candida, human milk, inflammation, lactoferrin
National Category
Pediatrics Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-151722DOI: 10.3390/nu10091227ISI: 000448659900100PubMedID: 30181494Scopus ID: 2-s2.0-85053077078OAI: oai:DiVA.org:umu-151722DiVA, id: diva2:1247077
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Västerbotten County CouncilAvailable from: 2018-09-11 Created: 2018-09-11 Last updated: 2018-11-26Bibliographically approved

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Granström, ElisabethStecksén-Blicks, ChristinaWest, Christina E.Silfverdal, Sven-Arne

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