umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Selenium-related transcriptional regulation of gene expression
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning, Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Xi’an, China. (Chondrogenic and Osteogenic Differentiation Group)ORCID-id: 0000-0002-6181-9904
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). (Chondrogenic and Osteogenic Differentiation Group)ORCID-id: 0000-0002-1710-7715
2018 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, nr 9, artikkel-id 2665Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

The selenium content of the body is known to control the expression levels of numerous genes, both so-called selenoproteins and non-selenoproteins. Selenium is a trace element essential to human health, and its deficiency is related to, for instance, cardiovascular and myodegenerative diseases, infertility and osteochondropathy called Kashin⁻Beck disease. It is incorporated as selenocysteine to the selenoproteins, which protect against reactive oxygen and nitrogen species. They also participate in the activation of the thyroid hormone, and play a role in immune system functioning. The synthesis and incorporation of selenocysteine occurs via a special mechanism, which differs from the one used for standard amino acids. The codon for selenocysteine is a regular in-frame stop codon, which can be passed by a specific complex machinery participating in translation elongation and termination. This includes a presence of selenocysteine insertion sequence (SECIS) in the 3'-untranslated part of the selenoprotein mRNAs. Nonsense-mediated decay is involved in the regulation of the selenoprotein mRNA levels, but other mechanisms are also possible. Recent transcriptional analyses of messenger RNAs, microRNAs and long non-coding RNAs combined with proteomic data of samples from Keshan and Kashin⁻Beck disease patients have identified new possible cellular pathways related to transcriptional regulation by selenium.

sted, utgiver, år, opplag, sider
MDPI, 2018. Vol. 19, nr 9, artikkel-id 2665
Emneord [en]
nonsense-mediated decay, selenium, selenocysteine, selenocysteine insertion sequence, selenoproteins
HSV kategori
Forskningsprogram
biokemi; cellforskning; medicinsk cellbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-151887DOI: 10.3390/ijms19092665ISI: 000449988100201PubMedID: 30205557Scopus ID: 2-s2.0-85053079645OAI: oai:DiVA.org:umu-151887DiVA, id: diva2:1248495
Forskningsfinansiär
Swedish Rheumatism AssociationTilgjengelig fra: 2018-09-15 Laget: 2018-09-15 Sist oppdatert: 2018-12-12bibliografisk kontrollert

Open Access i DiVA

fulltext(812 kB)83 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 812 kBChecksum SHA-512
668d36a52a43f01ae44b6d425c76f68e17cc9e10e9bd522b1fb9515f6a8e85e7efe3f1994e46b347fea3852309469db517293d36fc1ba4ce77252b6ac3ffc3f5
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Lammi, MikkoQu, Chengjuan

Søk i DiVA

Av forfatter/redaktør
Lammi, MikkoQu, Chengjuan
Av organisasjonen
I samme tidsskrift
International Journal of Molecular Sciences

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 83 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 142 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf