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Challenges in fabrication of tissue-engineered cartilage with correct cellular colonization and extracellular matrix assembly
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning, Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi'an Jiaotong University, Xi'an, China. (Chondrogenic and Osteogenic Differentiation Group)ORCID-id: 0000-0002-6181-9904
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Nordlab Kokkola, Keski-Pohjanmaa Central Hospital Soite, Kokkola, Finland. (Chondrogenic and Osteogenic Differentiation Group)
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). (Chondrogenic and Osteogenic Differentiation Group)
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). (Chondrogenic and Osteogenic Differentiation Group)ORCID-id: 0000-0002-1710-7715
2018 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, nr 9, artikkel-id 2700Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

A correct articular cartilage ultrastructure regarding its structural components and cellularity is important for appropriate performance of tissue-engineered articular cartilage. Various scaffold-based, as well as scaffold-free, culture models have been under development to manufacture functional cartilage tissue. Even decellularized tissues have been considered as a potential choice for cellular seeding and tissue fabrication. Pore size, interconnectivity, and functionalization of the scaffold architecture can be varied. Increased mechanical function requires a dense scaffold, which also easily restricts cellular access within the scaffold at seeding. High pore size enhances nutrient transport, while small pore size improves cellular interactions and scaffold resorption. In scaffold-free cultures, the cells assemble the tissue completely by themselves; in optimized cultures, they should be able to fabricate native-like tissue. Decellularized cartilage has a native ultrastructure, although it is a challenge to obtain proper cellular colonization during cell seeding. Bioprinting can, in principle, provide the tissue with correct cellularity and extracellular matrix content, although it is still an open question as to how the correct molecular interaction and structure of extracellular matrix could be achieved. These are challenges facing the ongoing efforts to manufacture optimal articular cartilage.

sted, utgiver, år, opplag, sider
MDPI, 2018. Vol. 19, nr 9, artikkel-id 2700
Emneord [en]
articular cartilage, cartilage architecture, cell colonization, extracellular matrix, tissue engineering
HSV kategori
Forskningsprogram
biokemi; cellforskning; ortopedi
Identifikatorer
URN: urn:nbn:se:umu:diva-151888DOI: 10.3390/ijms19092700ISI: 000449988100236PubMedID: 30208585Scopus ID: 2-s2.0-85053359968OAI: oai:DiVA.org:umu-151888DiVA, id: diva2:1248509
Tilgjengelig fra: 2018-09-16 Laget: 2018-09-16 Sist oppdatert: 2018-12-18bibliografisk kontrollert

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