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Cerebrospinal fluid lactate and neurological outcome after subarachnoid haemorrhage
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
2019 (Engelska)Ingår i: Journal of clinical neuroscience, ISSN 0967-5868, E-ISSN 1532-2653, Vol. 60, s. 63-67Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Increased lactate in cerebrospinal fluid (CSF) has been regarded as a marker for cerebral ischemia and damage in the central nervous system. The aim of this study was to evaluate if CSF-lactate was associated with; impaired cerebral circulation, outcome, sex, age, clinical condition or treatment after subarachnoid haemorrhage (SAH).

METHODS: This study consists of 33 patients (22 females, 11 males) with aneurysmal SAH treated at Umeå university hospital 2008-2009. Samples were obtained from external ventricular catheters 0-240 h after SAH. Normal CFS-lactate was defined as 1.2-2-1 mmol/L. Hunt & Hess scale assessed clinical condition. Impaired cerebral circulation was evaluated by clinical examination, transcranial doppler, CT-scan, and cerebral angiography. Glasgow outcome scale (GOS) evaluated outcome.

RESULTS: Seventy-nine CSF-lactate samples were analysed. CSF-lactate >2.1 mmol/L was found in 25/33 (76%) patients and in 50/79 (63%) samples. No difference in CSF-lactate levels was found over time. No association was found between patients with CSF-lactate >2.1 mmol/L and; sex, severity of clinical condition, impaired cerebral circulation or outcome. CSF-lactate >2.1 mmol/L was more common in patients ≥61 years of age (p = 0.04) and in patients treated with endovascular coiling compared to surgical clipping (p = 0.0001).

CONCLUSION: In patients with SAH, no association was found between increased CSF-lactate (>2.1 mmol/L) and severe clinical condition, impaired cerebral circulation or unfavourable outcome. Endovascular coiling and age ≥61 years was associated with CSF-lactate above >2.1 mmol/L.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 60, s. 63-67
Nyckelord [en]
Cerebral aneurysms, Cerebrospinal fluid, Cerebrovascular circulation, Critical care outcomes, Endovascular procedures, Lactic acid
Nationell ämneskategori
Anestesi och intensivvård Kirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-152935DOI: 10.1016/j.jocn.2018.10.025ISI: 000456753600011PubMedID: 30361053OAI: oai:DiVA.org:umu-152935DiVA, id: diva2:1259606
Forskningsfinansiär
KempestiftelsernaTillgänglig från: 2018-10-30 Skapad: 2018-10-30 Senast uppdaterad: 2019-02-26Bibliografiskt granskad

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Lindgren, CeciliaKoskinen, Lars-Owe

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Anestesiologi och intensivvårdKlinisk neurovetenskap
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Journal of clinical neuroscience
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