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Functional coherence of striatal resting-state networks is modulated by striatal iron content
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
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2018 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 183, p. 495-503Article in journal (Refereed) Published
Abstract [en]

Resting-state spontaneous fluctuations have revealed individual differences in the functional architecture of brain networks. Previous research indicates that the striatal network shows alterations in neurological conditions but also in normal aging. However, the neurobiological mechanisms underlying individual differences in striatal resting-state networks (RSNs) have been less explored. One candidate that may account for individual differences in striatal spontaneous activity is the level of local iron accumulation. Excessive iron in the striatum has been linked to a loss of structural integrity and reduced brain activity during task performance in aging. Using independent component analysis in a sample of 42 younger and older adults, we examined whether higher striatal iron content, quantified using relaxometry, underlies individual differences in spontaneous fluctuations of RSNs in general, and of the striatum in particular. Higher striatal iron content was linked to lower spontaneous coherence within both caudate and putamen RSNs regardless of age. No such links were observed for other RSNs. Moreover, the number of connections between the putamen and other RSNs was negatively associated with iron content, suggesting that iron modulated the degree of cross-talk between the striatum and cerebral cortex. Importantly, these associations were primarily driven by the older group. Finally, a positive association was found between coherence in the putamen and motor performance, suggesting that this spontaneous activity is behaviorally meaningful. A follow-up mediation analysis also indicated that functional connectivity may mediate the link between striatal iron and motor performance. Our preliminary findings suggest that striatal iron potentially accounts for individual differences in spontaneous striatal fluctuations, and might be used as a locus of intervention.

Place, publisher, year, edition, pages
Academic Press, 2018. Vol. 183, p. 495-503
Keywords [en]
Aging, Iron, Functional connectivity, Resting-state fMRI, Striatum
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-153542DOI: 10.1016/j.neuroimage.2018.08.036ISI: 000447750200043PubMedID: 30125714OAI: oai:DiVA.org:umu-153542DiVA, id: diva2:1265780
Funder
Swedish Research Council, 421-2014-940Swedish Research Council, 2016-01936Knut and Alice Wallenberg FoundationGun och Bertil Stohnes StiftelseStiftelsen Gamla TjänarinnorAvailable from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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Salami, Alireza

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Umeå Centre for Functional Brain Imaging (UFBI)Department of Integrative Medical Biology (IMB)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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