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Steering pluripotency and differentiation with N6-methyladenosine RNA modification
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences.
2019 (English)In: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, ISSN 1874-9399, E-ISSN 1876-4320, Vol. 1862, no 3, p. 394-402Article in journal (Refereed) Published
Abstract [en]

Chemical modifications of RNA provide a direct and rapid way to modulate the existing transcriptome, allowing the cells to adapt rapidly to the changing environment. Among these modifications, N6-methyladenosine (m6A) has recently emerged as a widely prevalent mark of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. m6A modification modulates a broad spectrum of biochemical processes, including mRNA decay, translation and splicing. Both m6A modification and the enzymes that control m6A metabolism are essential for normal development. In this review, we summarized the most recent findings on the role of m6A modification in maintenance of the pluripotency of embryonic stem cells (ESCs), cell fate specification, the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), and differentiation of stem and progenitor cells.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 1862, no 3, p. 394-402
Keywords [en]
Adipogenesis, Cellular differentiation, Embryonic stem cell, Epitranscriptomics, Hematopoietic stem cell, Induced pluripotent stem cell, METTL3, Myogenesis, N(6)-methyladenosine, Neurogenesis, RNA methylation, Spermatogenesis
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-153977DOI: 10.1016/j.bbagrm.2018.10.013ISI: 000462104500017PubMedID: 30412796OAI: oai:DiVA.org:umu-153977DiVA, id: diva2:1269592
Funder
Knut and Alice Wallenberg FoundationVästerbotten County CouncilThe Kempe Foundations, JCK-1723.1Swedish Research Council, 2017-01636
Note

This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert

Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2019-04-12Bibliographically approved

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Malla, SandhyaMelguizo-Sanchis, DarioAguilo, Francesca

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