umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Inflammatory markers in sera in patients diagnosed with mucosal lichen planus
Umeå University, Faculty of Medicine, Department of Odontology, School of Dentistry.
Umeå University, Faculty of Medicine, Department of Odontology, School of Dentistry.
2018 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

OBJECTIVE: Lichen planus is a disease that can affect both skin and mucosa, in some cases both at the same time. Among patients with lichen planus, the oral version of lichen planus (OLP) can be observed in 50 – 70 %. OLP is the most common chronic inflammatory disease of oral mucosa. Today it is known that OLP is an inflammatory condition but it is not known exactly what substances are prominent and active during this specific inflammatory process. The aim of this study was to examine inflammatory factors involved in OLP. METHODS: A total of 24 individuals were included in this prospective study. 15 of these were patients diagnosed with mucosal LP, whereas the other nine were healthy controls. Blood samples were taken from all participants and sent to Life Science Lab in Uppsala where they used Olinks inflammation panel to analyse inflammatory markers in the blood samples. RESULTS: There were differences in inflammatory factors in blood between the controls and patients with mucosal lichen planus. The inflammatory factors that contributed the most to this difference were IL-5, SCF, FGF-19 and FGF-21. CONCLUSIONS: Due to the differences between LP-patients and controls we can conclude that there are tendencies to an inflammatory process going on systemically involving different levels of mainly IL-5, SCF, FGF-19 and FGF-21. The inflammatory factors that contributed the most to the differences between the two groups are not the typical ones that have been the resulting elevated inflammatory factors in other previous studies.

Place, publisher, year, edition, pages
2018. , p. 19
Keywords [en]
oral lichen planus, mucosal lichen planus, inflammatory factors
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-154926OAI: oai:DiVA.org:umu-154926DiVA, id: diva2:1275508
Supervisors
Examiners
Available from: 2019-01-07 Created: 2019-01-06 Last updated: 2019-01-07Bibliographically approved

Open Access in DiVA

fulltext(11678 kB)10 downloads
File information
File name FULLTEXT01.pdfFile size 11678 kBChecksum SHA-512
5ac205ecc5b626282fffaeb77a92312e049c3ea4e12aa72e619d5b2d1612fb4285b56ae7bf69406c993811f51c68e8360389e7c3b078f0dd59919e2ef1ed49d1
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Hanna, Carola
By organisation
School of Dentistry
Dentistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 10 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 104 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf