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Updated European Association of Urology Guidelines for Cytoreductive Nephrectomy in Patients with Synchronous Metastatic Clear-cell Renal Cell Carcinoma
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.ORCID iD: 0000-0002-4121-3753
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2018 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 74, no 6, p. 805-809Article in journal (Refereed) Published
Abstract [en]

Cytoreductive nephrectomy (CN) has been the standard of care in patients with metastatic clear-cell renal cancer who present with the tumour in place. The CARMENA trial compared systemic therapy alone with CN followed by systemic therapy. This article outlines the new guidelines based on these data.

Patient summary: The CARMENA trial demonstrates that immediate cytoreductive nephrectomy should no longer be considered the standard of care in patients diagnosed with intermediate and poor risk metastatic renal cell carcinoma when medical treatment is required. However, the psychological burden poor risk patients experience hearing that removal of their primary tumour will not be beneficial, should be carefully considered. 

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 74, no 6, p. 805-809
Keywords [en]
Cytoreductive nephrectomy, EAU guidelines, Metastatic, Renal cell cancer, Sunitinib
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:umu:diva-154931DOI: 10.1016/j.eururo.2018.08.008ISI: 000450121100028PubMedID: 30177291OAI: oai:DiVA.org:umu-154931DiVA, id: diva2:1275564
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07Bibliographically approved

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