umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Carbonic Anhydrase 6 Gene Variation influences Oral Microbiota Composition and Caries Risk in Swedish adolescents
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-4430-8125
Umeå University, Faculty of Medicine, Department of Odontology.
Show others and affiliations
2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 452Article in journal (Refereed) Published
Abstract [en]

Carbonic anhydrase VI (CA6) catalyses the reversible hydration of carbon dioxide in saliva with possible pH regulation, taste perception, and tooth formation effects. This study assessed effects of variation in the CA6 gene on oral microbiota and specifically the acidophilic and caries-associated Streptococcus mutans in 17-year old Swedish adolescents (n = 154). Associations with caries status and secreted CA6 protein were also evaluated. Single Nucleotide Polymorphisms (27 SNPs in 5 haploblocks) and saliva and tooth biofilm microbiota from Illumina MiSeq 16S rDNA (V3-V4) sequencing and culturing were analysed. Haploblock 4 (rs10864376, rs3737665, rs12138897) CCC associated with low prevalence of S. mutans (OR (95% CI): 0.5 (0.3, 0.8)), and caries (OR 0.6 (0.3, 0.9)), whereas haploblock 4 TTG associated with high prevalence of S. mutans (OR: 2.7 (1.2, 5.9)) and caries (OR: 2.3 (1.2, 4.4)). The TTG-haploblock 4 (represented by rs12138897(G)) was characterized by S. mutans, Scardovia wiggsiae, Treponema sp. HOT268, Tannerella sp. HOT286, Veillonella gp.1 compared with the CCC-haploblock 4 (represented by rs12138897(C)). Secreted CA6 in saliva was weakly linked to CA6 gene variation. In conclusion, the results indicate that CA6 gene polymorphisms influence S. mutans colonization, tooth biofilm microbiota composition and risk of dental caries in Swedish adolescents.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 452
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-155838DOI: 10.1038/s41598-018-36832-zISI: 000456553400018PubMedID: 30679524OAI: oai:DiVA.org:umu-155838DiVA, id: diva2:1283654
Funder
Västerbotten County CouncilAvailable from: 2019-01-29 Created: 2019-01-29 Last updated: 2019-02-26Bibliographically approved

Open Access in DiVA

fulltext(6047 kB)64 downloads
File information
File name FULLTEXT01.pdfFile size 6047 kBChecksum SHA-512
f5f4619ca7ac409ce444d8a344fd40f68121cf890113a35cfff8a665ea9ad708fbaa2a6fee58c8e347bd590e203d455b46524a92f7d22e659b7b9d4264c78e5e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Esberg, AndersLif Holgerson, PernillaJohansson, Ingegerd

Search in DiVA

By author/editor
Esberg, AndersLif Holgerson, PernillaJohansson, Ingegerd
By organisation
Department of Odontology
In the same journal
Scientific Reports
Dentistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 64 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf