umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Associations of Psychopathic Traits With Local and Global Brain Network Topology in Young Adult Women
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR). Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; .
Show others and affiliations
2018 (English)In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, ISSN 2451-9022, Vol. 3, no 12, p. 1003-1012Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Psychopathic traits vary dimensionally in the population and are associated with multiple negative outcomes. The impaired integration theory (IIT) proposes that psychopathic traits are associated with abnormal neural network topology, such that disturbed integration of neural networks results in a self-perpetuating impairment in rapid integration and learning from multiple components of information. The IIT is based on findings from male offenders presenting high scores on all psychopathic traits. The present study investigated whether IIT predictions of topology abnormalities were associated with psychopathic traits, measured dimensionally, in young adult women with subsyndromal scores.

METHODS: Seventy-three women, with an average age of 25 years, were assessed using the Psychopathy Checklist-Revised and completed resting-state magnetic resonance imaging. Preprocessed time series from 90 anatomical regions were extracted to form connectivity matrices and used to calculate network topology based on graph theory. Correlations between total psychopathy and factor scores with both the raw connectivity matrix and global and local graph theory measures were computed.

RESULTS: Total psychopathy scores and behavioral factor scores were related to connectivity between several pairs of regions, primarily limbic/paralimbic. Psychopathic traits were not associated with global topology measures. Topology abnormalities, robust across network formation thresholds, were found in nodes of the default mode network and in hubs connecting several resting-state networks.

CONCLUSIONS: IIT predictions of abnormal topology of hubs and default mode network nodes with dimensionally measured psychopathic traits were confirmed in a sample of young women. Regional abnormalities, accompanied by preserved global topology, may underlie context-specific abnormal information processing and integration.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 3, no 12, p. 1003-1012
Keywords [en]
Connectivity, Default mode network, Graph theory, Psychopathy, Resting state, Topology
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-156122DOI: 10.1016/j.bpsc.2018.04.010ISI: 000494358600006PubMedID: 29945829Scopus ID: 2-s2.0-85048967797OAI: oai:DiVA.org:umu-156122DiVA, id: diva2:1285972
Funder
Stockholm County CouncilSwedish Foundation for Strategic Research Swedish Research CouncilVinnovaAvailable from: 2019-02-05 Created: 2019-02-05 Last updated: 2019-11-26Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Flodin, PärJokinen, Jussi

Search in DiVA

By author/editor
Flodin, PärJokinen, Jussi
By organisation
Umeå Centre for Functional Brain Imaging (UFBI)Centre for Demographic and Ageing Research (CEDAR)Psychiatry
In the same journal
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 100 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf