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Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study
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2019 (English)In: Epidemiology and Infection, ISSN 0950-2688, E-ISSN 1469-4409, Vol. 147, article id UNSP e35Article in journal (Refereed) Published
Abstract [en]

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening respiratory disease with a high case fatality rate; however, its risk factors remain unclear. We aimed to explore the influence of demographic factors, clinical manifestations and underlying comorbidities on mortality in MERS-CoV patients. Retrospective chart reviews were performed to identify all laboratory-confirmed cases of MERS-COV infection in Saudi Arabia that were reported to the Ministry of Health of Saudi Arabia between 23 April 2014 and 7 June 2016. Statistical analyses were conducted to assess the effect of sex, age, clinical presentation and comorbidities on mortality from MERS-CoV. A total of 281 confirmed MERS-CoV cases were identified: 167 (59.4%) patients were male and 55 (20%) died. Mortality predominantly occurred among Saudi nationals and older patients and was significantly associated with respiratory failure and shortness of breath. Of the 281 confirmed cases, 160 (56.9%) involved comorbidities, wherein diabetes mellitus, hypertension, ischemic heart disease, congestive heart failure, end-stage renal disease and chronic kidney disease were significantly associated with mortality from MERS-CoV and two or three comorbidities significantly affected the fatality rates from MERS-CoV. The findings of this study show that old age and the existence of underlying comorbidities significantly increase mortality from MERS-CoV.

Place, publisher, year, edition, pages
Cambridge University Press, 2019. Vol. 147, article id UNSP e35
Keywords [en]
Comorbidities, middle east respiratory syndrome coronavirus, mortality
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-155975DOI: 10.1017/S0950268818002923ISI: 000455339100034PubMedID: 30394248OAI: oai:DiVA.org:umu-155975DiVA, id: diva2:1286691
Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-02-07Bibliographically approved

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Mohamed, Nahla

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