umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Associations between repeated measure of plasma perfluoroalkyl substances and cardiometabolic risk factors
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.ORCID-id: 0000-0003-1227-6859
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 124, s. 58-65Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Perfluoroalkyl substances (PFAS) are persistent synthetic chemicals that may affect components of metabolic risk through the peroxisome proliferator-activated receptor but epidemiological data remain scarce and inconsistent.

Objective: To estimate associations between repeated measurements of the main PFAS in plasma and total cholesterol, triglycerides and hypertension among the control subjects from a population-based nested case-control study on diabetes type 2 in middle-aged women and men.

Methods: Participants (n = 187) were free of diabetes at both baseline and follow-up visits to the Västerbotten Intervention Programme, 10 years apart: during 1990 to 2003 (baseline) and 2001 to 2013 (follow-up). Participants left blood samples, completed questionnaires on diet and lifestyle factors, and underwent medical examinations, including measurement of blood pressure. PFAS and lipids were later determined in stored plasma samples. Associations for the repeated measurements were assessed using generalized estimating equations.

Results: Six PFAS exceeded the limit of quantitation. Repeated measures of PFAS in plasma, cardiometabolic risk factors and confounders, showed an average decrease of triglycerides from −0.16 mmol/l (95% confidence interval [CI]: −0.33, 0.02 for PFOA) to −0.26 mmol/l (95% CI: −0.50, −0.08 for PFOS), when comparing the highest tertile of PFAS plasma levels with the lowest. Associations based on average PFAS measurements and follow-up triglycerides revealed similar inverse associations, although attenuated. The estimates for cholesterol and hypertension were inconsistent and with few exception non-significant.

Conclusions: This study found inverse associations between PFAS and triglycerides, but did not support any clear link with either cholesterol or hypertension.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 124, s. 58-65
Emneord [en]
Cardiometabolic risk factors, Environmental epidemiology, Hypertension, Lipids, Plasma perfluoroalkyl substances, Prospective assessment, Repeated measurements
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-156228DOI: 10.1016/j.envint.2019.01.007ISI: 000457122700007PubMedID: 30639908Scopus ID: 2-s2.0-85059696116OAI: oai:DiVA.org:umu-156228DiVA, id: diva2:1287037
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-0758Västerbotten County CouncilSwedish Research Council, 2017-00822Tilgjengelig fra: 2019-02-08 Laget: 2019-02-08 Sist oppdatert: 2019-02-22bibliografisk kontrollert

Open Access i DiVA

fulltext(1230 kB)91 nedlastinger
Filinformasjon
Fil FULLTEXT02.pdfFilstørrelse 1230 kBChecksum SHA-512
32733d75338d51d8fc0f48f5cff6671a2c1489cf28a5ddf995d652075412422393ae94b030656e3c1d7babf2509a281c3021fe61ab664705d59025c903516947
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Bergdahl, Ingvar A.Tornevi, AndreasWennberg, MariaSommar, Johan

Søk i DiVA

Av forfatter/redaktør
Bergdahl, Ingvar A.Tornevi, AndreasWennberg, MariaSommar, Johan
Av organisasjonen
I samme tidsskrift
Environment International

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 91 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 211 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf