umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents
Department of Periodontology, School of Dentistry, Mohammed V University, Morocco.ORCID-id: 0000-0002-1224-9124
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. (Aa-gruppen)
Laboratory of Oral Microbiology and Biotechnology, School of Dentistry, Mohammed V University in Rabat, Morocco.
Department of Periodontology, School of Dentistry, Mohammed V University, Morocco.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Clinical and experimental dental research, ISSN 2057-4347, Vol. 5, nr 1, s. 44-51Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

It has previously been shown that the presence of Aggregatibacter actinomycetemcomitans in subgingival plaque is significantly associated with increased risk for clinical attachment loss. The highly leukotoxic JP2 genotype of this bacterium is frequently detected in adolescents with aggressive forms of periodontitis. The aims of the study were to quantify the levels of JP2 and non-JP2 genotypes of A. actinomycetemcomitans in saliva of Moroccan adolescents with the JP2 genotype earlier detected in the subgingival plaque. The salivary concentrations of inflammatory proteins were quantified and linked to the clinical parameters and microbial findings. Finally, a mouth rinse with leukotoxin-neutralizing effect was administrated and its effect on the levels the biomarkers and A. actinomycetemcomitans examined. The study population consisted of 22 adolescents that previously were found to be positive for the JP2 genotype in subgingival plaque. Periodontal registration and sampling of stimulated saliva was performed at baseline. A mouth rinse (active/placebo) was administrated, and saliva sampling repeated after 2 and 4 weeks rinse. The salivary levels of JP2 and non-JP2 were analyzed by quantitative PCR and inflammatory proteins by ELISA. Both the JP2 and the non-JP2 genotype were detected in all individuals with significantly higher levels of the non-JP2. Enhanced levels of the JP2 genotype of A. actinomycetemcomitans was significantly correlated to the presence of attachment loss (≥3 mm). Salivary concentrations of inflammatory biomarkers did not correlate to periodontal condition or levels of A. actinomycetemcomitans. The use of active or placebo leukotoxin-neutralizing mouth rinse did not significantly interfered with the levels of these biomarkers. Saliva is an excellent source for detection of A. actinomycetemcomitans on individual basis, and high levels of the JP2 genotype were significantly associated with the presence of clinical attachment loss.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. Vol. 5, nr 1, s. 44-51
Emneord [en]
Aggregatibacter actinomycetemcomitans, JP2 genotype, interleukin‐1β, quantitative PCR, saliva, virulence blocking
HSV kategori
Forskningsprogram
odontologi
Identifikatorer
URN: urn:nbn:se:umu:diva-157103DOI: 10.1002/cre2.156ISI: 000461560700007PubMedID: 30847232OAI: oai:DiVA.org:umu-157103DiVA, id: diva2:1295049
Tilgjengelig fra: 2019-03-09 Laget: 2019-03-09 Sist oppdatert: 2019-04-23bibliografisk kontrollert

Open Access i DiVA

fulltext(494 kB)59 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 494 kBChecksum SHA-512
f00d69af117109c5217c5d5647e0149e9a99c1474d6f7ce45445c38ce1fd3f5af2617b7e0c37518aa8fbfca85a54071f131450b467c8aad3a52d3808d983bb68
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Claesson, Rolf

Søk i DiVA

Av forfatter/redaktør
Ennibi, Oum KeltoumClaesson, RolfHaubek, DorteJohansson, Anders
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 59 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 148 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf