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The association between circulating endostatin levels and incident myocardial infarction
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. (Research unit Skellefteå)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. (Heart Centre)
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2018 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 52, no 6, p. 315-319Article in journal (Refereed) Published
Abstract [en]

Objective. Increased levels of circulating endostatin have been observed in patients with prevalent ischemic heart disease. However, the association between circulating endostatin, and incident myocardial infarction (MI) is less studied. Our main aim was to study the association between circulating endostatin and incident MI in the community adjusted for established cardiovascular risk factors in men and women.

Design. Circulating endostatin was measured in a nested case control study based on three large community-based Swedish cohorts, including 533 MI cases, and 1003 age-, sex- and cohort-matched controls. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with adjustments for established cardiovascular risk factors.

Results. Higher endostatin was associated with a higher incidence of MI independently of established cardiovascular risk factors (OR 1.19, 95% CI 1.03–1.37, p = .02), but this association was abolished after additional adjustment for C-reactive protein. Sex-stratified analyses suggest that the association was substantially stronger in women as compared to men.

Conclusions. In our community based sample, higher endostatin predicted incident myocardial infarction predominantly in women but not independently of CRP. Thus, our findings do not support a broad utility of endostatin measurements for the prediction of incident myocardial infarction in clinical practice.

Place, publisher, year, edition, pages
Taylor & Francis, 2018. Vol. 52, no 6, p. 315-319
Keywords [en]
Inflammation, extra cellular matrix, oxidative stress, myocardial infarction, community based cohort, endostatin
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-157804DOI: 10.1080/14017431.2018.1547839ISI: 000461087500004PubMedID: 30474426Scopus ID: 2-s2.0-85061809020OAI: oai:DiVA.org:umu-157804DiVA, id: diva2:1301708
Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-04-02Bibliographically approved

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Jansson, Jan-HåkanSöderberg, Stefan

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