Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The inflammatory potential of diet in determining cancer risk: a prospective investigation of two dietary pattern scores
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. (Arcum)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health. (Arcum)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0001-8540-6891
Show others and affiliations
2019 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 14, no 4, article id e0214551Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Inflammation-related mechanisms may contribute to the link between diet and cancer. We sought to investigate the inflammatory impact of diet on cancer risk using the Dietary inflammatory index (DII) and an adapted Mediterranean diet score (MDS).

METHODS: This population-based, prospective cohort study used self-reported dietary data from the Västerbotten Intervention Programme, including 100,881 participants, of whom 35,393 had repeated measures. Associations between dietary patterns and cancer risk were evaluated using Cox proportional hazards regression. We also used restricted cubic splines to test for potential non-linear associations.

RESULTS: A total of 9,250 incident cancer cases were diagnosed during a median follow-up of 15 years. The two dietary patterns were moderately correlated to each other and had similar associations with cancer risk, predominantly lung cancer in men (DII per tertile decrease: Hazard ratio (HR) 0.81 (0.66-0.99), MDS per tertile increase: HR 0.86 (0.72-1.03)), and gastric cancer in men (DII: 0.73 (0.53-0.99), MDS: 0.73 (0.56-0.96)). Associations were, in general, found to be linear. We found no longitudinal association between 10-year change in diet and cancer risk.

CONCLUSION: We confirm small, but consistent and statistically significant associations between a more anti-inflammatory or healthier diet and reduced risk of cancer, including a lower risk of lung and gastric cancer in men. The dietary indexes produced similar associations with respect to the risk of cancer.

Place, publisher, year, edition, pages
2019. Vol. 14, no 4, article id e0214551
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-158790DOI: 10.1371/journal.pone.0214551ISI: 000464349000016PubMedID: 30978193Scopus ID: 2-s2.0-85064346606OAI: oai:DiVA.org:umu-158790DiVA, id: diva2:1314354
Available from: 2019-05-08 Created: 2019-05-08 Last updated: 2023-03-23Bibliographically approved
In thesis
1. Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
Open this publication in new window or tab >>Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Inflammation och risk för kroniska sjukdomar med fokus på kolorektalcancer och inverkan av kostmönster
Place, publisher, year, edition, pages
Umeå, Sweden: Umeå university, 2020. p. 81
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 2099
Keywords
nutritional epidemiology, dietary patterns, epidemiology, cancer, colorectal cancer, chronic low-grade inflammation, biomarkers, metabolomics, nutritionsepidemiologi, kostmönster, epidemiologi, cancer, kolorektalcancer, kronisk låggradig inflammation, biomarkörer, metabolomik
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology Nutrition and Dietetics
Research subject
Epidemiology
Identifiers
urn:nbn:se:umu:diva-176737 (URN)978-91-7855-366-2 (ISBN)978-91-7855-365-5 (ISBN)
Public defence
2020-12-11, Hörsal B, Unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2020-11-20 Created: 2020-11-16 Last updated: 2022-05-12Bibliographically approved

Open Access in DiVA

fulltext(2119 kB)380 downloads
File information
File name FULLTEXT01.pdfFile size 2119 kBChecksum SHA-512
fc394052ccba26afa7214cbf604b43d53fc540cb26389ed0665c94ecfcb9bed7fcacb5d6000c4f3d8f054a0a32478af91991495c06b1aaba19456ec1dcfbf1ee
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Bodén, StinaMyte, RobinWennberg, MariaHarlid, SophiaJohansson, Ingegerdvan Guelpen, BethanyNilsson, Lena Maria

Search in DiVA

By author/editor
Bodén, StinaMyte, RobinWennberg, MariaHarlid, SophiaJohansson, Ingegerdvan Guelpen, BethanyNilsson, Lena Maria
By organisation
OncologyNutritional ResearchSection of Sustainable HealthSchool of DentistryWallenberg Centre for Molecular Medicine at Umeå University (WCMM)Arctic Research Centre at Umeå University
In the same journal
PLOS ONE
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 380 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1294 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf