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The inflammatory potential of diet in determining cancer risk: a prospective investigation of two dietary pattern scores
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0001-8540-6891
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2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 4, article id e0214551Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Inflammation-related mechanisms may contribute to the link between diet and cancer. We sought to investigate the inflammatory impact of diet on cancer risk using the Dietary inflammatory index (DII) and an adapted Mediterranean diet score (MDS).

METHODS: This population-based, prospective cohort study used self-reported dietary data from the Västerbotten Intervention Programme, including 100,881 participants, of whom 35,393 had repeated measures. Associations between dietary patterns and cancer risk were evaluated using Cox proportional hazards regression. We also used restricted cubic splines to test for potential non-linear associations.

RESULTS: A total of 9,250 incident cancer cases were diagnosed during a median follow-up of 15 years. The two dietary patterns were moderately correlated to each other and had similar associations with cancer risk, predominantly lung cancer in men (DII per tertile decrease: Hazard ratio (HR) 0.81 (0.66-0.99), MDS per tertile increase: HR 0.86 (0.72-1.03)), and gastric cancer in men (DII: 0.73 (0.53-0.99), MDS: 0.73 (0.56-0.96)). Associations were, in general, found to be linear. We found no longitudinal association between 10-year change in diet and cancer risk.

CONCLUSION: We confirm small, but consistent and statistically significant associations between a more anti-inflammatory or healthier diet and reduced risk of cancer, including a lower risk of lung and gastric cancer in men. The dietary indexes produced similar associations with respect to the risk of cancer.

Place, publisher, year, edition, pages
2019. Vol. 14, no 4, article id e0214551
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Cancer and Oncology
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URN: urn:nbn:se:umu:diva-158790DOI: 10.1371/journal.pone.0214551ISI: 000464349000016PubMedID: 30978193OAI: oai:DiVA.org:umu-158790DiVA, id: diva2:1314354
Available from: 2019-05-08 Created: 2019-05-08 Last updated: 2019-05-27Bibliographically approved

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Bodén, StinaMyte, RobinWennberg, MariaHarlid, SophiaJohansson, Ingegerdvan Guelpen, BethanyNilsson, Lena Maria

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Bodén, StinaMyte, RobinWennberg, MariaHarlid, SophiaJohansson, Ingegerdvan Guelpen, BethanyNilsson, Lena Maria
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OncologyNutritional ResearchSection of Sustainable HealthSchool of DentistryWallenberg Centre for Molecular Medicine at Umeå University (WCMM)Arctic Research Centre at Umeå University
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