umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sinus node dysfunction in patients with Fontan circulation: could heart rate variability be a predictor for pacemaker implantation?
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.ORCID iD: 0000-0002-1313-0934
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Show others and affiliations
2019 (English)In: Pediatric Cardiology, ISSN 0172-0643, E-ISSN 1432-1971, Vol. 40, no 4, p. 685-693Article in journal (Refereed) Published
Abstract [en]

Sinus node dysfunction (SND) causes significant morbidity in patients after Fontan surgery. Heart rate variability (HRV) reflects the autonomic regulation of the heart, and changes in HRV have been associated with SND in adults. We aimed to study whether changes in HRV could be detected in 24-h electrocardiographic (ECG) recordings in Fontan patients with SND. We compared HRV results from two patient groups; patients with Fontan circulation who later required a pacemaker due to severe SND (n = 12) and patients with Fontan circulation and SND, without indication for pacemaker treatment (n = 11), with two control groups; patients with Fontan circulation without SND (n = 90) and healthy controls (n = 66). The Poincare plot index SD2 (representing changes in heart rate over 24-h) and the very low-frequency (VLF) HRV component were significantly higher in both SND groups, both compared with healthy controls and patients with Fontan circulation without SND. In SND patients with pacemakers, SD2 and VLF were slightly reduced compared to SND patients without pacemaker (p = 0.06). In conclusion, in Fontan patients with SND the HRV is significantly higher compared to healthy controls and Fontan patients without SND. However, in patients with severe SND requiring pacemaker, SD2 and VLF tended to be lower than in patients with SND without pacemaker, which could indicate a reduced diurnal HRV in addition to the severe bradycardia. This is a small study, but our results indicate that HRV analysis might be a useful method in the follow-up of Fontan patients regarding development of SND.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2019. Vol. 40, no 4, p. 685-693
Keywords [en]
Congenital heart disease, Fontan circulation, Pacemaker, Sinus node dysfunction, Heart rate variability, Poincare analysis
National Category
Cardiac and Cardiovascular Systems Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-158740DOI: 10.1007/s00246-019-02092-5ISI: 000463707500002PubMedID: 30918992OAI: oai:DiVA.org:umu-158740DiVA, id: diva2:1316642
Available from: 2019-05-20 Created: 2019-05-20 Last updated: 2019-05-20Bibliographically approved

Open Access in DiVA

fulltext(921 kB)35 downloads
File information
File name FULLTEXT01.pdfFile size 921 kBChecksum SHA-512
a7e7be2ded3abadfe5061c273e3f018437b6023b4ae41a81180e6217f818b4a54da32b60abb783478ed4fb65bdd7b726db29dbf0b372b13a39be65a7771379dd
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Alenius Dahlqvist, JennyWiklund, UrbanRydberg, Annika

Search in DiVA

By author/editor
Alenius Dahlqvist, JennyWiklund, UrbanHanseus, KatarinaRydberg, Annika
By organisation
PaediatricsDepartment of Radiation Sciences
In the same journal
Pediatric Cardiology
Cardiac and Cardiovascular SystemsPediatrics

Search outside of DiVA

GoogleGoogle Scholar
Total: 35 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 356 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf