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Increased use of cross-sectional imaging for follow-up does not improve post-recurrence survival of surgically treated initially localized RCC: results from a European multicenter database (RECUR)
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2019 (Engelska)Ingår i: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 53, nr 1, s. 14-20Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Modality and frequency of image-based renal cell carcinoma (R.C.C.) follow-up strategies are based on risk of recurrence. Using the R.E.C.U.R.-database, frequency of imaging was studied in regard to prognostic risk groups. Furthermore, it was investigated whether imaging modality utilized in contemporary follow-up were associated with outcome after detection of recurrence. Moreover, outcome was compared based on whether the assessment of potential curability was a pre-defined set of criteria's (per-protocol) or stated by the investigator. Materials and methods: Consecutive non-metastatic R.C.C. patients (n = 1,612) treated with curative intent at 12 institutes across eight European countries between 2006 and 2011 were included. Leibovich or U.I.S.S. risk group, recurrence characteristics, imaging modality, frequency and survival were recorded. Primary endpoints were overall survival (O.S.) after detection of recurrence and frequency of features associated with favourable outcome (non-symptomatic recurrences and detection within the follow-up-programme). Results: Recurrence occurred in 336 patients. Within low, intermediate and high risk for recurrence groups, the frequency of follow-up imaging was highest in the early phase of follow-up and decreased significantly over time (p < 0.001). However, neither the image modality for detection nor >= 50% cross-sectional imaging during follow-up were associated with improved O.S. after recurrence. Differences between per protocol and investigator based assessment of curability did not translate into differences in O.S. Conclusions: As expected, the frequency of imaging was highest during early follow-up. Cross-sectional imaging use for detection of recurrences following surgery for localized R.C.C. did not improve O.S. post-recurrence. Prospective studies are needed to determine the value of imaging in follow-up.

Ort, förlag, år, upplaga, sidor
Taylor & Francis Group, 2019. Vol. 53, nr 1, s. 14-20
Nyckelord [en]
Renal cell carcinoma, follow-up, imaging, overall survival
Nationell ämneskategori
Urologi och njurmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-159078DOI: 10.1080/21681805.2019.1588919ISI: 000465741800001PubMedID: 30907214OAI: oai:DiVA.org:umu-159078DiVA, id: diva2:1316737
Tillgänglig från: 2019-05-20 Skapad: 2019-05-20 Senast uppdaterad: 2019-10-11Bibliografiskt granskad

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Ljungberg, Börje

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Fernandéz-Pello, SergioLjungberg, Börje
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Institutionen för kirurgisk och perioperativ vetenskap
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Scandinavian journal of urology
Urologi och njurmedicin

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