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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
Umeå University, Faculty of Medicine, Department of Odontology. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; .
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2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 2773Article in journal (Refereed) Published
Abstract [en]

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 10, article id 2773
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Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-161588DOI: 10.1038/s41467-019-10630-1ISI: 000472598400005PubMedID: 31235808OAI: oai:DiVA.org:umu-161588DiVA, id: diva2:1338348
Available from: 2019-07-22 Created: 2019-07-22 Last updated: 2019-07-22Bibliographically approved

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Shungin, DmitryFranks, Paul W.

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Shungin, DmitryHindy, GeorgeYu, Yau-HuaSofer, TamarFranks, Paul W.Timpson, Nicholas J.
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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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  • de-DE
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