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Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
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2019 (engelsk)Inngår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 144, nr 7, s. 1511-1521Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (>= 353 mu g/day) compared to the lowest (<241 mu g/day) was 0.81 (95% CI: 0.51, 1.31; p(trend) = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for >= 353 mu g/day vs. <241 mu g/day, p(trend) = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p(interaction) = 0.99). We found no association between dietary folate intake and PC risk in this large European study.

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John Wiley & Sons, 2019. Vol. 144, nr 7, s. 1511-1521
Emneord [en]
dietary folate intake, pancreatic cancer, EPIC study
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-162489DOI: 10.1002/ijc.31830ISI: 000457773000004PubMedID: 30178496OAI: oai:DiVA.org:umu-162489DiVA, id: diva2:1345595
Tilgjengelig fra: 2019-08-26 Laget: 2019-08-26 Sist oppdatert: 2019-08-26bibliografisk kontrollert

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