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Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOEɛ4 in the Betula Cohort
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health. Department of Laboratory Medicine, Lund University, Lund, Sweden..
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2019 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908Article in journal (Refereed) Epub ahead of print
Abstract [en]

It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer’s disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ɛ4 carriers than in non-carriers. Air pollution and interaction with APOE ɛ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ɛ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ɛ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ɛ4 carriers than in the total population.

Place, publisher, year, edition, pages
IOS Press, 2019.
Keywords [en]
Air pollution, Alzheimer’s disease, apolipoprotein E, dementia
National Category
Occupational Health and Environmental Health
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URN: urn:nbn:se:umu:diva-163266DOI: 10.3233/JAD-181037PubMedID: 31450491OAI: oai:DiVA.org:umu-163266DiVA, id: diva2:1350697
Available from: 2019-09-12 Created: 2019-09-12 Last updated: 2019-09-13

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Oudin, AnnaAndersson, JohnSundström, AnnaNordin Adolfsson, AnnelieOudin Åström, DanielAdolfsson, RolfForsberg, BertilNordin, Maria

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Oudin, AnnaAndersson, JohnSundström, AnnaNordin Adolfsson, AnnelieOudin Åström, DanielAdolfsson, RolfForsberg, BertilNordin, Maria
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Section of Sustainable HealthDepartment of PsychologyPsychiatry
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Journal of Alzheimer's Disease
Occupational Health and Environmental Health

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