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A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)ORCID iD: 0000-0002-7815-4494
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0001-7691-4392
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)ORCID iD: 0000-0001-6871-7663
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)ORCID iD: 0000-0003-0364-8964
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2020 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 59, no 2, p. 896-902Article in journal (Refereed) Published
Abstract [en]

The design of turn‐on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G‐quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition‐driven disaggregation (on‐signal) of an ultrabright coumarin‐quinazoline conjugate. The synthesized probe selectively lights‐up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label free molecular logic system. Finally, our molecule preferentially stains the G4‐rich nucleoli of cancer cells.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2020. Vol. 59, no 2, p. 896-902
Keywords [en]
aggregation, biosensor, DNA, G-quadruplex, logic gate
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Medical Biochemistry
Identifiers
URN: urn:nbn:se:umu:diva-164662DOI: 10.1002/anie.201912027ISI: 000497789300001PubMedID: 31644837Scopus ID: 2-s2.0-85075533982OAI: oai:DiVA.org:umu-164662DiVA, id: diva2:1365659
Funder
Knut and Alice Wallenberg Foundation, KAW2015-0189Swedish Research Council, VR-NT 2017-05235Swedish Research Council, VR-MH 2018-02651The Kempe Foundations, SMK-1632Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2023-09-05Bibliographically approved

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Deiana, MarcoChand, KaramJamroskovic, JanObi, IkennaChorell, ErikSabouri, Nasim

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Deiana, MarcoChand, KaramJamroskovic, JanObi, IkennaChorell, ErikSabouri, Nasim
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Department of Medical Biochemistry and BiophysicsDepartment of Chemistry
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Angewandte Chemie International Edition
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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