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Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Reumatologi. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM).
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Klinisk fysiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Reumatologi. Department of Rheumatology, Kristianstad Hospital, Kristianstad, Sweden.
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2019 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, nr 8, artikel-id e0220531Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: Patients with rheumatoid arthritis (RA) have an increased mortality and morbidity due to cardiovascular disease (CVD). In this prospective 5-year follow up of patients with RA, we analysed several biomarkers, known to be associated with atherosclerosis and/or inflammation in the general population. The aim of this study was to find out whether the RA-disease per se affect these biomarkers and if those could be associated with the progression of atherosclerosis, as measured by intima media thickness (IMT) among patients with early RA.

Methods: Patients from northern Sweden diagnosed with early RA, are consecutively recruited into an ongoing prospective study on CVD comorbidity. A subgroup of patients, aged ≤60 years (n = 71) was included for ultrasound measurements of IMT at inclusion (T0) and after 5 years (T5) together with age-sex-matched controls (n = 40). The patients were clinically assessed. Blood was analysed for lipids, ESR and CRP and several biomarkers known to be associated with atherosclerosis in the general population.

Results: At T0, the patients with RA had significantly lower levels of MIF and significantly higher levels of interleukin (IL)-18 and MIC-1 compared with controls. At T5, the patients with RA had significantly higher levels of pentraxin3, MIC-1, TNF-R2, ICAM-1, VCAM-1 and endostatin compared with controls. At T0 the levels of MPO correlated with DAS28, sCD40L with CRP and IL-18 with systolic blood pressure and Reynolds risk score. Using PLSR on a CVD-panel analysed with multiplex immunoassay, the patients with RA could be correctly classified into those who had a worsening in their IMT over the five years or not. Here, MMP3 was identified as influential.

Conclusions: This study indicates that the RA disease itself could affect several of the biomarkers in this study, and possibly also the processes involved in the development of atherosclerosis.

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Public Library of Science , 2019. Vol. 14, nr 8, artikel-id e0220531
Nationell ämneskategori
Reumatologi och inflammation
Identifikatorer
URN: urn:nbn:se:umu:diva-164650DOI: 10.1371/journal.pone.0220531ISI: 000484993600022PubMedID: 31381601Scopus ID: 2-s2.0-85070281863OAI: oai:DiVA.org:umu-164650DiVA, id: diva2:1365799
Tillgänglig från: 2019-10-25 Skapad: 2019-10-25 Senast uppdaterad: 2019-10-25Bibliografiskt granskad

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Södergren, AnnaKarp, KjellBengtsson, ChristineRantapää-Dahlqvist, SolbrittWållberg-Jonsson, Solveig

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Södergren, AnnaKarp, KjellBengtsson, ChristineRantapää-Dahlqvist, SolbrittWållberg-Jonsson, Solveig
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ReumatologiWallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)Klinisk fysiologi
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