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Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans
Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, S-141 04 Huddinge, Sweden.
Department of Biochemistry, University of Turku, FI-20014 Turku, Finland.
Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, S-141 04 Huddinge, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. (Aa-gruppen)
Vise andre og tillknytning
2019 (engelsk)Inngår i: Pathogens, ISSN 2076-0817, Vol. 8, nr 4, artikkel-id E222Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation. Because of the large genetic diversity within the species, both harmless and highly virulent genotypes of the bacterium have emerged. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present review, the virulence and pathogenicity properties of A. actinomycetemcomitans will be addressed.

sted, utgiver, år, opplag, sider
Basel: MDPI, 2019. Vol. 8, nr 4, artikkel-id E222
Emneord [en]
Aggregatibacter actinomycetemcomitans, biofilm, cytokine binding factors, cytolethal distending toxin, horizontal gene transfer, leukotoxin, lipopolysaccharides, outer membrane vesicles, proteomic
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-165083DOI: 10.3390/pathogens8040222ISI: 000506652300065PubMedID: 31698835Scopus ID: 2-s2.0-85074732943OAI: oai:DiVA.org:umu-165083DiVA, id: diva2:1368981
Forskningsfinansiär
Swedish Research Council, 2017-01198Västerbotten County Council, 7003193Tilgjengelig fra: 2019-11-09 Laget: 2019-11-09 Sist oppdatert: 2020-03-02bibliografisk kontrollert

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