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Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience. Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Universite catholique de Louvain, Bruxelles, Belgium.
Umeå University, Faculty of Medicine, Department of Medical Biosciences.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.ORCID iD: 0000-0002-6658-7874
2019 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, no 8, p. 327-338Article in journal (Refereed) Published
Abstract [en]

Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. Expression of NAPEPLD and PLA2G4E, coding for eCB anabolic enzymes, was higher in the tumour tissue than in non-malignant tissue. Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. It is concluded that the eCB system may be dysfunctional in SCCOT.

Place, publisher, year, edition, pages
2019. Vol. 37, no 8, p. 327-338
Keywords [en]
Squamous cell carcinoma of the oral tongue, endocannabinoids, cyclooxygenase-2, N-acyl- osphatidylethanolamine phospholipase D, monoacylglycerol lipase
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-163070DOI: 10.1080/07357907.2019.1638394ISI: 000482287600001PubMedID: 31423851OAI: oai:DiVA.org:umu-163070DiVA, id: diva2:1373491
Available from: 2019-11-27 Created: 2019-11-27 Last updated: 2019-11-27Bibliographically approved

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Alhouayek, MireilleBoldrup, LindaFowler, Christopher J

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