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Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper. Department of Neurosurgery, University Hospital of Northern Sweden, 901 85 Umeå, Sweden.ORCID-id: 0000-0002-8258-0699
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-6169-5155
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 145, nr 2, s. 287-294Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to an environment favorable for growth of malignant glioma. The MAO-A gene is located on the X-chromosome and has at least one functional genetic polymorphism. The aim of the present study was to explore possible effects of MAO-A genotype on development of glioblastoma in males.

Methods: Genotypes for 437 glioma cases and 876 population-based controls from the Swedish Glioma International Case–Control study (GICC) were compared. We analyzed the germline DNA using the Illumina Oncoarray. We selected seven single nucleotide polymorphisms (SNPs) located in the MAO-A gene, and imputed genotypes based on data from the 1000 genomes project. We used 1579 male glioblastoma cases and 1875 controls comprising the whole GICC cohort for subsequent validation of findings.

Results: The rs144551722 SNP was a significant predictor of development of glioblastoma in males (p-value = 0.0056) but not in females even after correction for multiple testing. We conducted haplotype analysis to confirm an association between MAO-A gene and risk of glioblastoma (p-value = 0.016). We found similar results in the validation sample.

Conclusions: These results suggest the possibility of a role for the MAO-A enzyme and the MAO-A gene in the development of glioblastoma in males.

sted, utgiver, år, opplag, sider
Springer, 2019. Vol. 145, nr 2, s. 287-294
Emneord [en]
MAOA genetics glioblastoma males
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-166478DOI: 10.1007/s11060-019-03294-wISI: 000496571900010PubMedID: 31556016OAI: oai:DiVA.org:umu-166478DiVA, id: diva2:1382158
Forskningsfinansiär
NIH (National Institute of Health), R01CA139020NIH (National Institute of Health), R01 CA139020Tilgjengelig fra: 2020-01-02 Laget: 2020-01-02 Sist oppdatert: 2020-01-02bibliografisk kontrollert

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Sjöberg, Rickard LWu, Wendy Yi-YingDahlin, Anna M.Melin, Beatrice S.

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