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The Chemokine CXCL16 Is a New Biomarker for Lymph Node Analysis of Colon Cancer Outcome
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Immunologi/immunkemi. Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.ORCID-id: 0000-0003-3631-6122
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Immunologi/immunkemi. Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Immunologi/immunkemi.
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2019 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, nr 22, artikkel-id 5793Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

hemokines are important in the development and progression of tumors. We investigated the expression of CXCL14 and CXCL16 in colon cancer. Expression of mRNA was assessed in primary tumors and lymph nodes and CXCL16 mRNA levels were correlated to patient’s survival. Protein expression was investigated by two-color immunofluorescence and immunomorphometry. CXCL14 and CXCL16 mRNA levels and protein expression were significantly higher in colon cancer primary tumors compared to apparently normal colon tissue. Positive cells were tumor cells, as revealed by anti-CEA and anti-EpCAM staining. CXCL16, but not CXCL14, mRNA levels were significantly higher in hematoxylin and eosin positive (H&E(+)) compared to H&E(−) colon cancer lymph nodes or control nodes (P < 0.0001). CXCL16 mRNA was expressed in 5/5 colon cancer cell lines while CXCL14 was expressed significantly in only one. Kaplan-Meier analysis revealed that colon cancer patients with lymph nodes expressing high or very high levels (7.2 and 11.4 copies/18S rRNA unit, respectively) of CXCL16 mRNA had a decreased mean survival time of 30 and 46 months at the 12-year follow-up (P = 0.04, P = 0.005, respectively). In conclusion, high expression of CXCL16 mRNA in regional lymph nodes of colon cancer patients is a sign of a poor prognosis.

sted, utgiver, år, opplag, sider
MDPI, 2019. Vol. 20, nr 22, artikkel-id 5793
Emneord [en]
chemokines, CXCL17, CEA, EpCAM, qRT-PCR, immunohistochemistry, immunomorphometry
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-167031DOI: 10.3390/ijms20225793ISI: 000502786800275PubMedID: 31752131OAI: oai:DiVA.org:umu-167031DiVA, id: diva2:1383945
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Swedish Research CouncilVästerbotten County CouncilTilgjengelig fra: 2020-01-09 Laget: 2020-01-09 Sist oppdatert: 2020-01-09bibliografisk kontrollert

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AbdelMageed, ManarAli, HaythamOhlsson, LinaHammarström, Marie-LouiseHammarström, StenSitohy, Basel

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