Globus pallidal deep brain stimulation for Tourette syndrome: Effects on cognitive functionShow others and affiliations
2019 (English)In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 69, p. 14-18Article in journal (Refereed) Published
Abstract [en]
Introduction: In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.
Methods: Patients were assessed at baseline (4 weeks prior to surgery) and at the end of each of the three-month blinded periods, with stimulation either ON or OFF. The patients were evaluated on tests of memory (California Verbal Learning Test-II (CVLT-II); Corsi blocks; Short Recognition Memory for Faces), executive function (D-KEFS Stroop color-word interference, verbal fluency, Trail-making test, Hayling Sentence Completion test), and attention (Paced Auditory Serial Addition Test, Numbers and Letters Test).
Results: GPiam-DBS did not produce any significant change in global cognition. Relative to pre-operative baseline assessment verbal episodic memory on the CVLT-II and set-shifting on the Trail-making Test were improved with DBS OFF. Performance on the cognitive tests were not different with DBS ON versus DBS OFF. GPiam-DBS did not alter aspects of cognition that are impaired in TS such as inhibition on the Stroop interference task or the Hayling Sentence Completion test.
Conclusions: This study extends previous findings providing data showing that GPiam-DBS does not adversely affect cognitive domains such as memory, executive function, verbal fluency, attention, psychomotor speed, and information processing. These results indicate that GPiam-DBS does not produce any cognitive deficits in TS.
Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 69, p. 14-18
Keywords [en]
Tourette syndrome, Deep brain stimulation, Globus pallidus, Cognitive function
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-167062DOI: 10.1016/j.parkreldis.2019.10.013ISI: 000503323700004PubMedID: 31648149Scopus ID: 2-s2.0-85073506828OAI: oai:DiVA.org:umu-167062DiVA, id: diva2:1383973
2020-01-092020-01-092023-03-23Bibliographically approved