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Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
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2019 (English)In: Pathogens, ISSN 2076-0817, Vol. 8, no 4, article id 243Article, review/survey (Refereed) Published
Abstract [en]

Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease. It has been cultured from non-oral infections for more than a century, while its portrayal as an aetiological agent in periodontitis has emerged more recently. A. actinomycetemcomitans is one species among a plethora of microorganisms that constitute the oral microbiota. Although A. actinomycetemcomitans encodes several putative toxins, the complex interplay with other partners of the oral microbiota and the suppression of host response may be central for inflammation and infection in the oral cavity. The aim of this review is to provide a comprehensive update on the clinical significance, classification, and characterisation of A. actinomycetemcomitans, which has exclusive or predominant host specificity for humans.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 8, no 4, article id 243
Keywords [en]
adherence, endocarditis, fimbriae, JP2, leukotoxin, periodontitis
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-167619DOI: 10.3390/pathogens8040243ISI: 000506652300086PubMedID: 31752205Scopus ID: 2-s2.0-85075623737OAI: oai:DiVA.org:umu-167619DiVA, id: diva2:1391865
Available from: 2020-02-05 Created: 2020-02-05 Last updated: 2020-02-05Bibliographically approved

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Claesson, RolfHöglund Åberg, Carola

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