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Chemical Composition, Antimicrobial activity, in Vitro Cytotoxicity and Leukotoxin Neutralization of Essential Oil from Origanum vulgare against Aggregatibacter actinomycetemcomitans
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. (Aa-gruppen)ORCID-id: 0000-0002-8069-8263
Aarhus University Denmark.
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2020 (engelsk)Inngår i: Pathogens, ISSN 2076-0817, Vol. 9, nr 3, artikkel-id 192Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this study, the essential oil of Origanum vulgare was evaluated for putative antibacterial activity against six clinical strains and five reference strains of Aggregatibacter actinomycetemcomitans, in comparison with some antimicrobials. The chemical composition of the essential oil was analyzed, using chromatography (CG) and gas chromatography-mass spectrometry coupled (CG-MS). The major compounds in the oil were Carvacrol (32.36%), α-terpineol (16.70%), p-cymene (16.24%), and Thymol (12.05%). The antimicrobial activity was determined by an agar well diffusion test. A broth microdilution method was used to study the minimal inhibitory concentration (MIC). The minimal bactericidal concentration (MBC) was also determined. The cytotoxicity of the essential oil (IC50) was <125 µg/mL for THP-1 cells, which was high in comparison with different MIC values for the A. actinomycetemcomitans strains. O. vulgare essential oil did not interfere with the neutralizing capacity of Psidium guajava against the A. actinomycetemcomitans leukotoxin. In addition, it was shown that the O. vulgare EO had an antibacterial effect against A. actinomycetemcomitans on a similar level as some tested antimicrobials. In view of these findings, we suggest that O.vulgare EO may be used as an adjuvant for prevention and treatment of periodontal diseases associated to A. actinomycetemcomitans. In addition, it can be used together with the previously tested leukotoxin neutralizing Psidium guajava.

sted, utgiver, år, opplag, sider
Basel: MDPI, 2020. Vol. 9, nr 3, artikkel-id 192
Emneord [en]
Aggregatibacter actinomycetemcomitans, periodontitis, Origanum vulgare, essential oil, antimicrobial activity, minimum inhibitory concentration, minimal bactericidal concentration, cytotoxicity, leukotoxin neutralization
HSV kategori
Forskningsprogram
biokemisk farmakologi
Identifikatorer
URN: urn:nbn:se:umu:diva-168855DOI: 10.3390/pathogens9030192ISI: 000524306100021PubMedID: 32151045OAI: oai:DiVA.org:umu-168855DiVA, id: diva2:1413900
Tilgjengelig fra: 2020-03-11 Laget: 2020-03-11 Sist oppdatert: 2020-04-27bibliografisk kontrollert

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