umu.sePublications
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association between serum level of urate and subclinical atherosclerosis: results from the SCAPIS Pilot
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
Show others and affiliations
2020 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 22, no 1, article id 37Article in journal (Refereed) Published
Abstract [en]

Background: Hyperuricemia is closely associated with cardiovascular disease (CVD). However, it has not been definitively established whether this association is independent of traditional cardiovascular risk factors (CVRFs) and whether it is gender-dependent. The aim of this study was to investigate in a population-based cohort (age range, 50-64 years) stratified by sex the association between the serum urate (SU) concentration and subclinical atherosclerosis, as reflected in the coronary artery calcification (CAC) score, common carotid intima-media thickness (CIMT), and carotid plaque score.

Methods: The study involved participants in the Swedish CArdioPulmonary bioImage Study (SCAPIS) Pilot cohort (N = 1040; 48.8% males). This pilot cohort is part of the large population-based SCAPIS with 30,000 participants in the age range of 50-64 years, aimed at improving risk prediction for CVD. Subjects with a self-reported previous history of CVD (N = 68) or gout (N = 3) were excluded. The CAC score was assessed with the Agatston method using computed tomography. CIMT and carotid plaques were quantified by ultrasound. The associations between the SU quartiles and different levels of CAC, CIMT, and carotid plaques were assessed by multivariable logistic regression.

Results: Age, BMI, education level, smoking, physical activity, hs-CRP, hypertension, and dyslipidemia showed no differences between males and females, while CAC (score > 0) and diabetes were both twice as common in men than in women (58% vs 26% and 8% vs 4%, respectively). Higher SU quartiles were in both sexes associated with BMI, hs-CRP, and the prevalence of hypertension, and in women, they were also associated with the prevalence of dyslipidemia. The three upper quartiles of SU (>308 mu mol/L) were linked to higher CAC scores in men, when adjusting for CVRFs, but not in women. CIMT and carotid plaques showed no correlation to SU in either sex.

Conclusions: Higher levels of SU are associated with the presence of CAC in men but not in women, whereas SU is not associated with CIMT or carotid plaques in either men or women. This implies that the biological effects of SU differ in men and women or that SU has varying effects on different vascular beds or during the different stages of the atherosclerotic process.

Place, publisher, year, edition, pages
BioMed Central, 2020. Vol. 22, no 1, article id 37
Keywords [en]
Serum urate, SCAPIS, Subclinical atherosclerosis, Coronary artery calcification, Intima-media thickness, Carotid plaque, Cardiovascular disease
National Category
Cardiac and Cardiovascular Systems Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-169101DOI: 10.1186/s13075-020-2119-0ISI: 000518012600004PubMedID: 32087742OAI: oai:DiVA.org:umu-169101DiVA, id: diva2:1415897
Available from: 2020-03-20 Created: 2020-03-20 Last updated: 2020-03-20Bibliographically approved

Open Access in DiVA

fulltext(937 kB)16 downloads
File information
File name FULLTEXT01.pdfFile size 937 kBChecksum SHA-512
c312a458de2b66c900bcfbcc87a8eacadb393b2990a2a8692c23c2626bccb989712e7b7f68f05a9b06c610bf5d84b7ba24d9b4d141103d05ee10a7404d1f26fc
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Forsblad-d'Elia, Helena

Search in DiVA

By author/editor
Forsblad-d'Elia, Helena
By organisation
Rheumatology
In the same journal
Arthritis Research & Therapy
Cardiac and Cardiovascular SystemsRheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 16 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf