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Unconventional Cyclic di-GMP Signaling in Escherichia coli
Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten). Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR). (Uhlin's Laboratory)ORCID-id: 0000-0003-3318-9084
Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR). Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).ORCID-id: 0000-0002-2991-8072
2020 (Engelska)Ingår i: Microbial Cyclic Di-Nucleotide Signaling / [ed] Chou, Shan-Ho; Guiliani, Nicolas; Lee, Vincent T.; Römling, Ute, Cham: Springer International Publishing , 2020, 1, s. 487-517Kapitel i bok, del av antologi (Övrigt vetenskapligt)
Abstract [en]

The species Escherichia coli represents an unfathomable variety of commensal, pathogenic, and environmental strains. The conventional cyclic di-GMP signaling in E. coli controls sessility-motility changes linked to commensalism and/or pathogenicity. Extraintestinal Pathogenic E. coli (ExPEC) are “commensals” that can cause an array of infections outside the gastrointestinal tract. To accommodate their pathogenic lifestyle with the commensal one, ExPEC biology is shaped not only by the presence of specific virulence genes and pathoadaptive mutations but also by regulatory adaptations. Bioinformatic and genetic studies indicate that the cyclic di-GMP signaling network is included in the adaptation process. For example, some neuroinvasive ExPEC were found to maintain reduced cyclic di-GMP levels due to RpoS deactivation, resulting in loss of appearance of the rugose morphotype. Moreover, ExPEC has a diversified repertoire of cyclic di-GMP degrading enzymes obtained by acquisition of novel genes often associated with fimbrial biogenesis gene clusters (e.g., sfaY/papY/focY) and by modification or deletion of specific core genome genes. For example, the majority of ExPEC contains a shortened allelic variant of the ycgG gene and some ExPEC strains do not even carry the genetic locus. New combinations of regulators offer a new cyclic di-GMP platform for S-fimbrial biogenesis and for new metabolic capabilities leading to citrate utilization and ferric citrate uptake. In this review, we outline the prerequisites for the unconventional signaling network, the rationale behind its existence in ExPEC, and future perspectives in studies of ExPEC.

Ort, förlag, år, upplaga, sidor
Cham: Springer International Publishing , 2020, 1. s. 487-517
Nyckelord [en]
ExPEC, NMEC, Pathoadaptation, RpoS, Citrate, Ferric citrate, S-fimbriae
Nationell ämneskategori
Naturvetenskap Medicin och hälsovetenskap
Forskningsämne
mikrobiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-169131DOI: 10.1007/978-3-030-33308-9_29ISBN: 978-3-030-33307-2 (tryckt)ISBN: 978-3-030-33308-9 (digital)OAI: oai:DiVA.org:umu-169131DiVA, id: diva2:1416098
Forskningsfinansiär
Vetenskapsrådet, 2015-03007Vetenskapsrådet, 2015-06824Vetenskapsrådet, 2016-06598Vetenskapsrådet, 349-2007-8673Vetenskapsrådet, 829-2006-7431Tillgänglig från: 2020-03-21 Skapad: 2020-03-21 Senast uppdaterad: 2020-03-23Bibliografiskt granskad

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Zlatkov, NikolaUhlin, Bernt Eric

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Zlatkov, NikolaUhlin, Bernt Eric
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Institutionen för molekylärbiologi (Medicinska fakulteten)Molekylär Infektionsmedicin, Sverige (MIMS)Umeå Centre for Microbial Research (UCMR)
NaturvetenskapMedicin och hälsovetenskap

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