umu.sePublications
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Improvement in indices of cellular protection after psychological treatment for social anxiety disorder
Show others and affiliations
2019 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 9, article id 340Article in journal (Refereed) Published
Abstract [en]

Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 340
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-169117DOI: 10.1038/s41398-019-0668-2ISI: 000518228100001PubMedID: 31852887OAI: oai:DiVA.org:umu-169117DiVA, id: diva2:1416534
Funder
Swedish Research Council, 2016-0228Swedish Research Council, 201500387Swedish Research Council, 2014-10171The Swedish Brain Foundation, FO2016-0106The Swedish Brain Foundation, FO2018-0255Available from: 2020-03-24 Created: 2020-03-24 Last updated: 2020-03-24Bibliographically approved

Open Access in DiVA

fulltext(1451 kB)3 downloads
File information
File name FULLTEXT01.pdfFile size 1451 kBChecksum SHA-512
356684dcfe69cb75c217f38dcaafd4cf36e79da7eb53e1d18df0d28fdcac8b9beeff9cae159bf250bff9d31b7bc547d0185ff388033c2ff563c9fea21584062f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Boraxbekk, Carl-Johan

Search in DiVA

By author/editor
Yang, Liu L.Nilsonne, GustavBoraxbekk, Carl-Johan
By organisation
Centre for Demographic and Ageing Research (CEDAR)
In the same journal
Translational Psychiatry
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
Total: 3 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf