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Smoke exposure increases the risk for multiple sclerosis.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurologi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och folkhälsovetenskap.ORCID-id: 0000-0002-5095-3454
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.ORCID-id: 0000-0001-9581-3845
2008 (Engelska)Ingår i: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 15, nr 6, s. 579-583Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose and methods: To estimate the effect of exposure to smoking on the risk for multiple sclerosis (MS), we analyzed nicotine metabolite (cotinine) levels in biobank samples from 109 MS cases and 218 matched referents.

Results: Elevated cotinine levels, even modest elevations, were associated with an increased risk for MS (all other categories versus lowest: OR = 2.9; 95% CI: 1.3–6.3). A similar but non-significant risk increase was observed also in the small subset of individuals with samples collected before the onset of MS (all other categories versus lowest: OR = 2.4; 95% CI: 0.26–21). Elevated cotinine was associated with an increased risk for MS predominantly in women (all other categories versus lowest category: OR = 3.9; 95% CI: 1.3–12), whereas the risk increase in men was smaller and non-significant.

Discussion: Smoke exposure is associated with a higher risk for MS than previously estimated. There seems to be a threshold effect present in the lower range of cotinine in its relation to MS. Modestly elevated cotinine levels suggestive of passive smoking are associated with an increased risk for MS. Smoke exposure may explain the higher incidence of MS in women. These preliminary findings need to be confirmed in an expanded material of prospectively collected samples.

 

Ort, förlag, år, upplaga, sidor
Oxford: Rapid Communications , 2008. Vol. 15, nr 6, s. 579-583
Nyckelord [en]
Adolescent, Adult, Aged, Cotinine/*blood, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Multiple Sclerosis/*blood/*epidemiology, Risk Factors, Smoking/*adverse effects, cotinine, gender difference, multiple sclerosis, passive smoking, smoke exposure
Identifikatorer
URN: urn:nbn:se:umu:diva-10445PubMedID: 18474075OAI: oai:DiVA.org:umu-10445DiVA, id: diva2:150116
Tillgänglig från: 2008-09-15 Skapad: 2008-09-15 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Sundström, PeterNyström, LennarthHallmans, Göran

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