umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Yrkes- och miljömedicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Yrkes- och miljömedicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.ORCID-id: 0000-0001-9581-3845
Visa övriga samt affilieringar
2006 (Engelska)Ingår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 100, nr 3, s. 330-338Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
2006. Vol. 100, nr 3, s. 330-338
Nyckelord [en]
Adult, Aged, Body Burden, Cadmium/*analysis, Dental Amalgam/chemistry, Diet, Environmental Exposure, Environmental Monitoring, Erythrocytes/chemistry, Female, Food Contamination, Humans, Lead/*analysis, Life Style, Male, Mercury/*analysis, Middle Aged, Seafood, Smoking/adverse effects, Sweden
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
folkhälsa
Identifikatorer
URN: urn:nbn:se:umu:diva-15397DOI: 10.1016/j.envres.2005.08.013PubMedID: 16221471OAI: oai:DiVA.org:umu-15397DiVA, id: diva2:155069
Tillgänglig från: 2007-12-07 Skapad: 2007-12-07 Senast uppdaterad: 2018-08-31Bibliografiskt granskad
Ingår i avhandling
1. Biomarkers of fish consumption and risk of stroke or myocardial infarction
Öppna denna publikation i ny flik eller fönster >>Biomarkers of fish consumption and risk of stroke or myocardial infarction
2010 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The effect of fish consumption on the risk of cardiovascular disease has been extensively studied. Omega-3 fatty acids present in fish, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been found to have beneficial effects through several mechanisms. In addition, selenium, an antioxidant, may be protective. Fish also represents the main human exposure source to the pollutant methylmercury (MeHg), which is associated with elevated cardiovascular risk in previous studies. The aim of this thesis was to evaluate whether MeHg is associated with the risk of myocardial infarction (MI) or stroke, whether EPA+DHA or selenium (Se) have protective associations, and if the overall association between fish consumption and risk of stroke or MI is detrimental or protective.

A prospective incident case-control study design was used to study effects on stroke or MI. Three hundred and sixty-nine cases with twice as many matched controls were included in the study on stroke, while 431 cases with 499 controls participated in the MI study, all from the Northern Sweden Health and Disease Study. The data was collected from health examinations of the population from 1986 until 1999. Also, time trends in burdens of mercury (Hg), lead (Pb) and cadmium (Cd) in erythrocytes (Ery) from 1990 to 1999 were examined. The food frequency questionnaire (FFQ) used in the case-control studies was correlated with measurements of fatty acids in erythrocyte membranes as biomarkers of intake.

In this northern Swedish population, levels of Ery-Hg and Ery-Pb decreased during the 1990´s, but Ery-Cd decreased only in smoking men. No significant associations were found between Ery-Hg or levels of EPA+DHA and the risk of stroke. Men reporting fish consumption >3 meals/week had an elevated risk of stroke. In the MI study, higher levels of Ery-Hg were associated with lower risk of MI. No clear associations were found for reported fish consumption, levels of EPA+DHA or Ery-Se. The validated FFQ has a fair reliability in estimating intake of fatty acids EPA and DHA. However, the low variation in fish consumption in the general population in combination with different versions of the FFQ (with pre-defined, multiple choice alternatives) decreased the reliability of self-reported fish consumption in the case-control studies on risk of stroke or MI.

In conclusion, MeHg has no harmful association regarding the risk of stroke or MI in this population with generally low exposure levels. The protective association regarding risk of MI is probably due to Ery-Hg being a biomarker for consumption of fish, a source of other beneficial nutrients. Thus, in this population the benefits of the nutrients in fish appear to overcome the potential harm of MeHg.

The finding of elevated stroke risk related to high fish consumption in men will be investigated further.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå university, 2010. s. 46
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1356
Nyckelord
fish consumption, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, methylmercury, selenium, lead, cadmium, stroke, myocardial infarction, erythrocytes, food frequency questionnaire
Nationell ämneskategori
Arbetsmedicin och miljömedicin
Forskningsämne
epidemiologi; hälso- och sjukvårdsforskning; medicin; biologi, miljövetenskap; näringslära
Identifikatorer
urn:nbn:se:umu:diva-33906 (URN)978-91-7459-008-1 (ISBN)
Disputation
2010-06-04, FORUM-salen, Campus Skeria, Skellefteå, 13:00 (Svenska)
Opponent
Handledare
Projekt
PHIME; Public health impact of long-term, low-level mixed element exposure in susceptible population strata
Tillgänglig från: 2010-05-21 Skapad: 2010-05-10 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16221471&dopt=Citation

Personposter BETA

Wennberg, MariaBergdahl, Ingvar AHallmans, GöranJansson, Jan-HåkanStegmayr, Birgitta

Sök vidare i DiVA

Av författaren/redaktören
Wennberg, MariaBergdahl, Ingvar AHallmans, GöranJansson, Jan-HåkanStegmayr, Birgitta
Av organisationen
Yrkes- och miljömedicinNäringsforskningMedicin
I samma tidskrift
Environmental Research
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 180 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf