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Comparison of three instrumental methods for the objective evaluation of radiotherapy induced erythema in breast cancer patients and a study of the effect of skin lotions
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
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2007 (Engelska)Ingår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 46, nr 7, s. 893-899Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A non-blinded three armed study of the effect of Aloe vera, Essex and no lotion on erythema was performed. The erythema is an effect of radiotherapy treatment in breast cancer patients. The study required testing of objective methods for measuring the erythema. The chosen experimental methods were Near Infrared Spectroscopy, Laser Doppler Imaging and Digital Colour Photography. The experimental setup was made in such a way that in parallel with testing the effect of the lotions there was also a test of the sensitivity of the instruments. Fifty women were selected consecutively to participate in the study. They were all subjected to treatment with high-energy electrons (9-20 MeV) after mastectomy, 2Gy/day to a total dose of 50 Gy. Measurements were performed before the start of radiotherapy and thereafter once a week during the course of treatment. Aloe vera and Essex lotion were applied twice every radiation day in selected sites. The increase in skin redness could be monitored with all techniques with a detection limit of 8 Gy for Digital Colour Photography and Near Infrared Spectroscopy and 18 Gy for Laser Doppler Imaging. In clinical practice our recommendation is to use Digital Colour Photography. No significant median differences were observed between the pairs no lotion-Essex, no lotion-Aloe vera and Essex-Aloe vera for any of the techniques tested.

Ort, förlag, år, upplaga, sidor
Oslo: Taylor & Francis, 2007. Vol. 46, nr 7, s. 893-899
Nyckelord [en]
Aloe-vera gel, double-blind, radiation dermatitis, phase-III, cream, therapy, tissue
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-16795DOI: 10.1080/02841860701ISI: 000249872900002PubMedID: 17917821OAI: oai:DiVA.org:umu-16795DiVA, id: diva2:156468
Tillgänglig från: 2007-11-20 Skapad: 2007-11-20 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Ingår i avhandling
1. Multivariate non-invasive measurements of skin disorders
Öppna denna publikation i ny flik eller fönster >>Multivariate non-invasive measurements of skin disorders
2006 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The present thesis proposes new methods for obtaining objective and accurate diagnoses in modern healthcare. Non-invasive techniques have been used to examine or diagnose three different medical conditions, namely neuropathy among diabetics, radiotherapy induced erythema (skin redness) among breast cancer patients and diagnoses of cutaneous malignant melanoma. The techniques used were Near-InfraRed spectroscopy (NIR), Multi Frequency Bio Impedance Analysis of whole body (MFBIA-body), Laser Doppler Imaging (LDI) and Digital Colour Photography (DCP).

The neuropathy for diabetics was studied in papers I and II. The first study was performed on diabetics and control subjects of both genders. A separation was seen between males and females and therefore the data had to be divided in order to obtain good models. NIR spectroscopy was shown to be a viable technique for measuring neuropathy once the division according to gender was made. The second study on diabetics, where MFBIA-body was added to the analysis, was performed on males exclusively. Principal component analysis showed that healthy reference subjects tend to separate from diabetics. Also, diabetics with severe neuropathy separate from persons less affected.

The preliminary study presented in paper III was performed on breast cancer patients in order to investigate if NIR, LDI and DCP were able to detect radiotherapy induced erythema. The promising results in the preliminary study motivated a new and larger study. This study, presented in papers IV and V, intended to investigate the measurement techniques further but also to examine the effect that two different skin lotions, Essex and Aloe vera have on the development of erythema. The Wilcoxon signed rank sum test showed that DCP and NIR could detect erythema, which is developed during one week of radiation treatment. LDI was able to detect erythema developed during two weeks of treatment. None of the techniques could detect any differences between the two lotions regarding the development of erythema.

The use of NIR to diagnose cutaneous malignant melanoma is presented as unpublished results in this thesis. This study gave promising but inconclusive results. NIR could be of interest for future development of instrumentation for diagnosis of skin cancer.

Ort, förlag, år, upplaga, sidor
Umeå: Kemi, 2006. s. 46
Nyckelord
Multivariate Data Analysis, Non-invasive techniques, Clinical studies, Principal Component Analysis, Partial Least Squares Discriminant Analysis, Wilcoxon Signed Rank Sum Test, Near-InfraRed spectroscopy, Frequency Bio Impedance Analysis of whole body, Laser Doppler Imaging, Digital Colour Photography
Nationell ämneskategori
Analytisk kemi
Identifikatorer
urn:nbn:se:umu:diva-865 (URN)91-7264-154-1 (ISBN)
Disputation
2006-10-06, KB3A9, KBC-huset, Umeå, 10:30
Opponent
Handledare
Tillgänglig från: 2006-09-14 Skapad: 2006-09-14 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Nyström, JosefinaSvensk, Ann-ChristineLindholm-Sethson, BrittaFranzén, Lars

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