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Reducing intracranial pressure may increase survival among patients with bacterial meningitis
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar. (Clas Ahlm)
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
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2004 (Engelska)Ingår i: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 38, nr 3, s. 384-390Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We reported findings concerning continuous intracranial pressure (ICP) and cerebral perfusion pressure (CPP) measurements and mortality in patients with severe bacterial meningitis treated on the basis of an ICP-targeted approach. Eighteen patients with severe bacterial meningitis were admitted for neurointensive care at Umeå University Hospital (Umeå, Sweden). In 15 patients, ICP was measured continuously through an ICP measuring device. During care, all patients but one developed intracranial hypertension with an ICP of ⩾15 mm Hg (14 [93%] of 15 patients). Ten (67%) of 15 patients survived and were discharged, and 5 patients (33%) died. Mean ICP was significantly higher and CPP was markedly decreased in nonsurvivors, compared with survivors. Among the survivors, ICP was gradually reduced. Treatment of patients with severe bacterial meningitis should include neurointensive care and continuous ICP measurement. Increased ICP may be reduced by using the ICP-targeted therapy that closely resembles the “Lund concept.”

Ort, förlag, år, upplaga, sidor
Chicago: Univ. of Chicago Press , 2004. Vol. 38, nr 3, s. 384-390
Nyckelord [en]
Adolescent, Adult, Child, Preschool, Female, Humans, Infant, Intracranial Hypertension/etiology/mortality/*therapy, Intracranial Pressure, Male, Meningitis, Bacterial/*mortality/physiopathology, Middle Aged, Survival Analysis
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-18103DOI: 10.1086/380970PubMedID: 14727209OAI: oai:DiVA.org:umu-18103DiVA, id: diva2:157776
Tillgänglig från: 2008-01-08 Skapad: 2008-01-08 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Lindvall, PeterAhlm, ClasGothefors, LeifNaredi, SilvanaKoskinen, Lars-Owe D

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Lindvall, PeterAhlm, ClasGothefors, LeifNaredi, SilvanaKoskinen, Lars-Owe D
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NeurokirurgiInfektionssjukdomarPediatrikAnestesiologi och intensivvård
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Clinical Infectious Diseases
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