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A reduced level of consciousness affects non-conscious processes
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Nursing.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.ORCID iD: 0000-0002-2113-8098
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2021 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 244, article id 118571Article in journal (Refereed) Published
Abstract [en]

Being conscious is a profound aspect of human existence, and understanding its function and its inception is considered one of the truly grand scientific challenges. However, the nature of consciousness remains enigmatic, to a large part because “being conscious” can refer to both the content (phenomenology) and the level (arousal) of consciousness, and how these different aspects are related remains unclear. To empirically assess the relation between level and content of consciousness, we manipulated these two aspects by presenting stimuli consciously or non-consciously and by using Propofol sedation, while brain activity was measured using fMRI. We observed that sedation affected both conscious and non-conscious processes but at different hierarchical levels; while conscious processing was altered in higher-order regions (the intraparietal sulcus) and spared sensory areas, the opposite effect was observed for non-conscious processing. The observation that Propofol affected non-conscious processing calls for a reconsideration of what kind of information one can gain on “consciousness” from recording neural responses to sedation without considering both (content) conscious and (content) non-conscious processing.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 244, article id 118571
Keywords [en]
Brain activity, Consciousness, fMRI, Sedation, Unconscious
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-187741DOI: 10.1016/j.neuroimage.2021.118571ISI: 000696967000002PubMedID: 34509624Scopus ID: 2-s2.0-85114794464OAI: oai:DiVA.org:umu-187741DiVA, id: diva2:1597837
Funder
Riksbankens Jubileumsfond, P17-0772:1Available from: 2021-09-28 Created: 2021-09-28 Last updated: 2023-05-02Bibliographically approved

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Fontan, AurelieLindgren, LenitaPedale, TizianaBrorsson, CamillaEriksson, Johan

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Fontan, AurelieLindgren, LenitaPedale, TizianaBrorsson, CamillaEriksson, Johan
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Department of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Department of NursingAnaesthesiology
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NeuroImage
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