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LSD1: Expanding functions in stem cells and differentiation
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0001-7652-1695
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-2374-2045
2021 (English)In: Cells, E-ISSN 2073-4409, Vol. 10, no 11, article id 3252Article, review/survey (Refereed) Published
Abstract [en]

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific deme-thylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethyl-ates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of nu-merous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory cir-cuitry underlying self-renewal and pluripotency.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 10, no 11, article id 3252
Keywords [en]
Differentiation, Embryonic stem cells, Epigenetics, Histone methylation, Induced pluripotent stem cells, KDM1A, LSD1, Lysine-specific demethylase, Non-his-tone substrate, Pluripotency, Self-renewal
National Category
Cell and Molecular Biology
Research subject
Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-189925DOI: 10.3390/cells10113252ISI: 000724414100001PubMedID: 34831474Scopus ID: 2-s2.0-85119274398OAI: oai:DiVA.org:umu-189925DiVA, id: diva2:1614993
Available from: 2021-11-29 Created: 2021-11-29 Last updated: 2023-09-05Bibliographically approved

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Martinez-Gamero, CarlosMalla, SandhyaAguilo, Francesca

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Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Department of Molecular Biology (Faculty of Medicine)
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Cells
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