Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis: a longitudinal Swedish study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.ORCID iD: 0000-0002-3822-0725
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry.ORCID iD: 0000-0001-5025-6539
Show others and affiliations
2021 (English)In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 60, no 9, p. 4085-4093Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.

METHODS: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.

RESULTS: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed.

CONCLUSION: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.

Place, publisher, year, edition, pages
Oxford University Press, 2021. Vol. 60, no 9, p. 4085-4093
Keywords [en]
IgA anti-CD74, outcomes research, radiographic axial spondyloarthritis ankylosing spondylitis
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-191231DOI: 10.1093/rheumatology/keaa882ISI: 000710982100036PubMedID: 33369649Scopus ID: 2-s2.0-85114422689OAI: oai:DiVA.org:umu-191231DiVA, id: diva2:1629212
Funder
Swedish Research Council, 2016-02035Region Västerbotten, ALFVLL-640251Stiftelsen Konung Gustaf V:s 80-årsfond, FAI-2017-0454Available from: 2022-01-17 Created: 2022-01-17 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

fulltext(285 kB)126 downloads
File information
File name FULLTEXT01.pdfFile size 285 kBChecksum SHA-512
653a8619b45fcb8c35070073203a8a98e488dcedf262725613b758d4f3839a70610c036f2889b467eabb349904ccdda4428bf2314a9caed3ef173192c2d28c71
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Granåsen, GabrielHellman, UrbanLejon, KristinaForsblad-d'Elia, Helena

Search in DiVA

By author/editor
Granåsen, GabrielHellman, UrbanLejon, KristinaForsblad-d'Elia, Helena
By organisation
RheumatologyDepartment of Public Health and Clinical MedicineImmunology/Immunchemistry
In the same journal
Rheumatology
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 126 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 213 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf