Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0002-9599-0961
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Show others and affiliations
2023 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 68, p. 608-615Article in journal (Refereed) Published
Abstract [en]

Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown.

Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden.

Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to goblet cells, and pancreas antigen) were analyzed in 123 subjects with preclinical ulcerative colitis (UC), 54 subjects with preclinical Crohn's disease (CD) and in 390 sex- and age-matched controls. In addition, in a subset of subjects, inflammatory markers (CRP, albumin, calprotectin and ferritin) were measured in plasma.

Results: The mean years between blood samples and IBD diagnosis were for UC 5.1 (SD 3.5) years and CD 5.6 (SD 3.5) years. There was no difference in the proportion of overall positive antibodies between subjects who later developed IBD compared to controls (16.9% vs. 12.3%; p = 0.137). The subjects who later developed CD had a significantly higher proportion of positive ASCA compared to controls (9.3% vs 2.8%; p = 0.034), but for all other antibodies, there were no differences compared to control subjects. Subjects with preclinical IBD and elevated antibodies showed significantly higher plasma calprotectin levels compared to subjects without antibodies (980 μg/L vs 756 μg/L; p = 0.042), but there was no difference in the levels of CRP, albumin and ferritin.

Conclusions: We found no significant increase in antibodies typical for IBD years before diagnosis except for ASCA, which was slightly more common in subjects who later developed CD. Very few subjects had detectable antibodies to goblet cells and pancreas antigen.

Place, publisher, year, edition, pages
Springer, 2023. Vol. 68, p. 608-615
Keywords [en]
ASCA, Calprotectin, Crohn's disease, Inflammatory bowel disease, Ulcerative colitis
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-199100DOI: 10.1007/s10620-022-07630-5ISI: 000842443300007PubMedID: 35989383Scopus ID: 2-s2.0-85136572563OAI: oai:DiVA.org:umu-199100DiVA, id: diva2:1703790
Funder
Swedish Research Council, VR 2017-00650Umeå UniversityRegion VästerbottenAvailable from: 2022-10-14 Created: 2022-10-14 Last updated: 2023-06-19Bibliographically approved

Open Access in DiVA

fulltext(616 kB)90 downloads
File information
File name FULLTEXT02.pdfFile size 616 kBChecksum SHA-512
420e33e5dd40d581ec8364da0db4ac74f06037d56c89c8cc8b18c9fa5c0c4a4bf693496cfc830d1f327cd678840574d22a5d498ce36fea65a2fefcd22271cac1
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Widbom, LovisaHultdin, JohanEriksson, CatharinaKarling, Pontus

Search in DiVA

By author/editor
Widbom, LovisaHultdin, JohanEriksson, CatharinaKarling, Pontus
By organisation
Department of Clinical MicrobiologyClinical chemistrySection of Medicine
In the same journal
Digestive Diseases and Sciences
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
Total: 151 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 363 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf