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Acute pericarditis as a major clinical manifestation of long COVID-19 syndrome
Centro Medico Sant'Agostino, Milano, Italy; University Clinical Centre of Kosova, Kosovo, Prishtina.
Salus Itinere, Livorno, Italy.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine. University Clinical Centre of Kosova, Prishtina, Kosovo.ORCID iD: 0000-0002-8996-4257
Department of Clinical and Experimental Medicine, University of Pisa, Italy.
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2023 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 374, p. 129-134Article in journal (Refereed) Published
Abstract [en]

Background: The long COVID-19 syndrome has been recently described and some reports have suggested that acute pericarditis represents important manifestation of long COVID-19 syndrome. The aim of this study was to identify the prevalence and clinical characteristics of patients with long COVID-19, presenting with acute pericarditis.

Methods: We retrospectively included 180 patients (median age 47 years, 62% female) previously diagnosed with COVID-19, exhibiting persistence or new-onset symptoms ≥12 weeks from a negative naso-pharyngeal SARS CoV2 swamp test. The original diagnosis of COVID-19 infection was determined by a positive swab. All patients had undergone a thorough physical examination. Patients with suspected heart involvement were referred to a complete cardiovascular evaluation. Echocardiography was performed based on clinical need and diagnosis of acute pericarditis was achieved according to current guidelines.

Results: Among the study population, shortness of breath/fatigue was reported in 52%, chest pain/discomfort in 34% and heart palpitations/arrhythmias in 37%. Diagnosis of acute pericarditis was made in 39 patients (22%). Mild-to-moderate pericardial effusion was reported in 12, while thickened and bright pericardial layers with small effusions (< 5 mm) with or without comet tails arising from the pericardium (pericardial B-lines) in 27. Heart palpitations/arrhythmias (OR:3.748, p = 0.0030), and autoimmune disease and allergic disorders (OR:4.147, p = 0.0073) were independently related to the diagnosis of acute pericarditis, with a borderline contribution of less likelihood of hospitalization during COVID-19 (OR: 0.100, p = 0.0512).

Conclusion: Our findings suggest a high prevalence of acute pericarditis in patients with long COVID-19 syndrome. Autoimmune and allergic disorders, and palpitations/arrhythmias were frequently associated with pericardial disease.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 374, p. 129-134
Keywords [en]
Acute pericarditis, COVID-19, SARS-CoV2
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-202257DOI: 10.1016/j.ijcard.2022.12.019ISI: 000963714400001PubMedID: 36513284Scopus ID: 2-s2.0-85144783643OAI: oai:DiVA.org:umu-202257DiVA, id: diva2:1724216
Available from: 2023-01-05 Created: 2023-01-05 Last updated: 2023-06-19Bibliographically approved

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Bytyci, IbadeteBajraktari, GaniHenein, Michael Y.

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