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Incidence and mortality of infective endocarditis in the last decade: a single center study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy; Department of Cardiovascular Disease - AUSL Romagna, Division of Cardiology, Ravenna, United States.
Department of Cardiovascular Disease - AUSL Romagna, Division of Cardiology, Ravenna, United States; Cardiology Unit and LTTA Centre, University of Ferrara, Ferrara, Italy.
Department of Cardiovascular Disease - AUSL Romagna, Division of Cardiology, Ravenna, United States.
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
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2023 (English)In: Journal of Cardiovascular Medicine, ISSN 1558-2027, E-ISSN 1558-2035, Vol. 24, no 2, p. 105-112Article, review/survey (Refereed) Published
Abstract [en]

BACKGROUND: Infective endocarditis (IE) is a significant disease characterized by high mortality and complications. The aim of this study was to evaluate the incidence/100 000 inhabitants and the in-hospital mortality/100 000 inhabitants of IE during the last 10 years in the province of Ravenna.

METHODS AND RESULTS: We reviewed the public hospitals discharge database from January 2010 to December 2020 using the international classification of disease codification (ICD-9) for IE. We used the Italian national statistical institute (ISTAT) archive to estimate the number of Ravenna inhabitants/year. In 10 years, we identified a total of 407 patients with diagnosis of IE.The incidence of IE increased significantly from 6.29 cases/100 000 inhabitants in 2010 to 19.58 cases/100 000 inhabitants in 2020 ( P  < 0.001). Also, the in-hospital mortality from IE increased over the same number of years, from 1.8 deaths/100 000 inhabitants in 2010 to 4.4 deaths/100 000 inhabitants in 2020 ( P  < 0.001). The mortality rate (%) of IE over the years did not increase ( P = 0.565). Also, over the years there was no difference in the site of infection ( P  = 0.372), irrespective of the valve localization or type, native valve ( P  = 0.347) or prosthetic valve ( P  = 0.145). On logistic regression analysis, age was the only predictor of in-hospital mortality (odds ratio 1.045, 95% confidence interval: 1.015; 1.075, P  = 0.003).

CONCLUSIONS: Ravenna-based data on IE showed increased disease incidence but unchanged mortality rate over 10 years of follow-up. Age remains the sole predictor of population-based mortality, irrespective of the nature of the valve, native or substitute, and the organism detected on microbiology.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2023. Vol. 24, no 2, p. 105-112
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-203793DOI: 10.2459/JCM.0000000000001410ISI: 000906008100004PubMedID: 36574285Scopus ID: 2-s2.0-85145425219OAI: oai:DiVA.org:umu-203793DiVA, id: diva2:1729435
Available from: 2023-01-20 Created: 2023-01-20 Last updated: 2023-09-05Bibliographically approved

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Lisi, MatteoHenein, Michael Y.

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