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Parallel G-quadruplex DNA structures from nuclear and mitochondrial genomes trigger emission enhancement in a nonfluorescent nano-aggregated fluorine-boron-based dye
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0002-7815-4494
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0001-7691-4392
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0003-2523-1940
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0002-4541-7702
2023 (English)In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 14, no 7, p. 1862-1869Article in journal (Refereed) Published
Abstract [en]

Molecular self-assembly is a powerful tool for the development of functional nanostructures with adaptive optical properties. However, in aqueous solution, the hydrophobic effects in the monomeric units often afford supramolecular architectures with typical side-by-side π-stacking arrangement with compromised emissive properties. Here, we report on the role of parallel DNA guanine quadruplexes (G4s) as supramolecular disaggregating-capture systems capable of coordinating a zwitterionic fluorine-boron-based dye and promoting activation of its fluorescence signal. The dye's high binding affinity for parallel G4s compared to nonparallel topologies leads to a selective disassembly of the dye's supramolecular state upon contact with parallel G4s. This results in a strong and selective disaggregation-induced emission that signals the presence of parallel G4s observable by the naked eye and inside cells. The molecular recognition strategy reported here will be useful for a multitude of affinity-based applications with potential in sensing and imaging systems.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2023. Vol. 14, no 7, p. 1862-1869
National Category
Physical Chemistry
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URN: urn:nbn:se:umu:diva-205385DOI: 10.1021/acs.jpclett.2c03301ISI: 000936590300001PubMedID: 36779779Scopus ID: 2-s2.0-85148521026OAI: oai:DiVA.org:umu-205385DiVA, id: diva2:1742695
Available from: 2023-03-10 Created: 2023-03-10 Last updated: 2023-09-05Bibliographically approved

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Deiana, MarcoChand, KaramChorell, ErikSabouri, Nasim

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