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Early adulthood exercise capacity, but not muscle strength, associates with subclinical atherosclerosis 40 years later in Swedish men
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0003-3488-7781
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-0923-5813
Umeå University, Faculty of Medicine, Department of Radiation Sciences.ORCID iD: 0000-0003-4288-1208
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation.ORCID iD: 0000-0002-4341-1745
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2023 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 30, no 5, p. 407-415Article in journal (Refereed) Published
Abstract [en]

AIMS: Poor exercise capacity and muscle strength in early adulthood are risk factors for cardiovascular disease (CVD). However, it is unclear how these factors relate to subclinical atherosclerosis due to a lack of longitudinal studies. This study investigated whether early adulthood exercise capacity and muscle strength associated with later adulthood subclinical atherosclerosis.

METHODS AND RESULTS: This study included Swedish men (n = 797) who were eligible for military conscription (at ∼18-years of age) and who participated in the baseline assessment of the visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention trial between 2013 and 2016 (at 60 years of age). At conscription, isometric muscle strength (dynamometer) and maximum exercise capacity (maximal load cycle ergometer test) were measured. During later adulthood (at 60 years old), the presence of carotid plaques and intima media thickness were measured by using high-resolution ultrasound. At follow-up, plaques were present in 62% (n = 493) of men. Exercise capacity in early adulthood associated with 19% lower odds of plaques [odds ratio (OR) 0.81, 95% confidence interval (CI) 0.68-0.96], independent of muscle strength. This association was not mediated by any single CVD risk factor. However, the total indirect effect of later, but not early, adulthood CVD risk factors was significant, while the direct effect was non-significant (OR 0.85, 95% CI 0.71-1.02). Associations between muscle strength and subclinical atherosclerosis were non-significant.

CONCLUSION: Higher exercise capacity during early adulthood, but not muscle strength, may protect against carotid plaque development during adulthood mediated by the combination rather than a single later adulthood CVD risk factors.

Place, publisher, year, edition, pages
Oxford University Press, 2023. Vol. 30, no 5, p. 407-415
Keywords [en]
Carotid intima media thickness, Carotid plaques, Exercise capacity, Longitudinal study, Muscle strength
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-206445DOI: 10.1093/eurjpc/zwad007ISI: 000913889800001PubMedID: 36631734Scopus ID: 2-s2.0-85151044376OAI: oai:DiVA.org:umu-206445DiVA, id: diva2:1750443
Funder
Region Västerbotten, ALFVLL-298001Region Västerbotten, ALFVLL-643391Swedish Research Council, 521-2013-2708Swedish Research Council, 2016-01891Swedish Heart Lung Foundation, 20150369Swedish Heart Lung Foundation, 20170481Swedish Society of MedicineThe Swedish Stroke AssociationAFA InsuranceVisare NorrAvailable from: 2023-04-13 Created: 2023-04-13 Last updated: 2023-04-13Bibliographically approved

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Fortuin-de Smidt, MelonyBergman, FridaGrönlund, ChristerHult, AndreasNorberg, MargaretaWennberg, MariaWennberg, Patrik

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Fortuin-de Smidt, MelonyBergman, FridaGrönlund, ChristerHult, AndreasNorberg, MargaretaWennberg, MariaWennberg, Patrik
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Department of Public Health and Clinical MedicineDepartment of Radiation SciencesDepartment of Community Medicine and Rehabilitation
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European Journal of Preventive Cardiology
Cardiac and Cardiovascular SystemsPublic Health, Global Health, Social Medicine and Epidemiology

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